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Montelukast & Levocetrizine

Montelukast & Levocetrizine

About Montelukast & Levocetrizine

A leukotriene receptor antagonist,Montelukastis used to treat asthma, hay fever and seasonal allergy symptoms. It prevents asthma attacks and breathing problems caused by exercise. It works by blocking leukotriene which in turn decreases certain asthma and allergic symptoms.

Dosage

For treatment of allergic rhinitis and chronic asthma (Adults):

Consider administration of 10 mg once a day in the evening.

For Prophylaxis of exercise-induced asthma (Adults):

Consider administration of 10 mg of Montelukast + Levocetirizine, at least two hours before exercise.

Mechanism of Action of Montelukast 10mg + Levocetirizine 5mg:

Montelukast Is A Selective Leukotriene Receptor Antagonist That Blocks The Effects Of Cysteinyl Leukotrienes In The Airways. Absorption: Rapidly Absorbed From The GI Tract (Oral). Peak Plasma Concentrations In 2-4 Hr. Mean Oral Bioavailability: 64%. Distribution: Protein-Binding: >99%. Metabolism: Extensively Hepatic By CYP3A4, CYP2A6 And CYP2C9 Isoenzymes. Excretion: Principally Via Faeces; Elimination Half-Life Prolonged In Mild To Moderate Hepatic Impairment.

Drug Interactions

Metabolism May Be Increased With Rifampicin, Phenobarbital, Phenytoin. Peripheral Oedema May Occur With Prednisone.

Side effects

In addition to its intended effect, Montelukast may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.

  • Headache
  • Stomach pain
  • Chest tightness
  • Joint pain
  • Difficulty in swallowing
  • Pus in urine

Precautions

Montelukast + Levocetirizine is contraindicated in patients with an allergy to either or both drugs, hepatic impairment, NSAID allergy, Churg-Strauss syndrome.

Montelukast + Levocetirizine is contraindicated in children less than six months of age.

Montelukast + Levocetirizine can cause dizziness. Do not drive vehicles or operate heavy machineries that need alertness.

Montelukast+Levocetirizine and Lactation

It is unclear whether the drug could pass through the breast milk to a breast feeding baby. Consult your physician before taking Montelukast + Levocetirizine, if you are nursing mother.

Montelukast+Levocetirizine and Children

No information available

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