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Mexiletine HCL

Mexiletine HCL

About Mexiletine HCL

Mexitil Capsules (mexiletine hydrochloride) is an antiarrhythmic drug prescribed for the treatment of certain types of ventricular arrhythmias. The brand name drug Mexitil is no longer available in the U.S. Generic versions may be available. Common side effects of Mexitil (mexiletine hydrochloride) include nausea, vomiting, upset stomach, heartburn, decreased appetite, headache, blurred vision, rash, dizziness, lightheadedness, tiredness, poor coordination, dry mouth, diarrhea, constipation, weakness, numbness, tingling, tremor (shaking), ringing in your ears, or depression.

Side effects

  • Dizziness or lightheadedness
  • heartburn
  • nausea and vomiting
  • nervousness
  • trembling or shaking of the hands
  • unsteadiness or difficulty in walking

How does Mexiletine Hydrochloride Capsule work?

Mexiletine is well absorbed orally and has a bioavailability of approximately 85%. It is primarily excreted in the urine although approximately 10% is metabolized by the liver and excreted in the feces. The half-life of this drug may be prolonged in animals with reduced cardiac output, or after an acute myocardial infarction. The half-life may also be prolonged in animals with hepatic dysfunction or severe kidney disease.

What special precautions are there?

Mexiletine should be used with extreme caution in animals with the following conditions: 2nd or 3rd degree AV heart block, intraventricular conduction abnormality, sinus node function abnormality, cardiogenic shock, congestive heart failure, myocardial infarction, liver dysfunction, hypotension, or seizure disorders.

Precautions

Mexiletine should be used with extreme caution in animals with the following conditions: 2nd or 3rd degree AV heart block, intraventricular conduction abnormality, sinus node function abnormality, cardiogenic shock, congestive heart failure, myocardial infarction, liver dysfunction, hypotension, or seizure disorders.

Drug Interactions

Concurrent use with lidocaine increases the likelihood of adverse effects.

There are a number of drugs that may cause drug interactions either through changing the rate of absorption or changing the rate of metabolism of mexiletine. This list includes: antacids, atropine, opiates, cimetidine, griseofulvin, metoclopramide, phenobarbital, phenytoin, primidone, rifampin, theophylline.

Drugs that change urinary acidity may affect the renal excretion of mexiletine. These drugs include methionine, ammonium chloride, potassium phosphate, sodium phosphate, citrates, sodium bicarbonate, and carbonic anhydrase inhibitors.

Warnings:

Hepatic impairment. Severe heart failure. Sinus node dysfunction or intraventricular conduction defects. Hypotension. Epilepsy. Monitor ECG, blood and liver function. Pregnancy (Cat.C). Nursing mothers: not recommended.

Storage

Store at 20°C to 25°C (68°F to 77°F).

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