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Metolazone is used to treat fluid retention (edema) and swelling that is caused by congestive heart failure, kidney disease, or other medical conditions .

Metolazone is also used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the work load of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled .

How should this medicine be used?

Metolazone comes as a tablet to take by mouth. It is usually taken once a day. Take metolazone at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take metolazone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of metolazone and gradually increase your dose, depending on your response to this medication.

How it works

Metolazone belongs to a class of drugs called diuretics. A class of drugs is a group of medications that work in a similar way. They’re often used to treat similar conditions. Diuretics work by causing you to urinate more. This helps remove excess fluid and salt from your body. Removing this excess fluid and salt also helps to lower your blood pressure.

Metolazone and Other Drug Interactions

Tell your doctor about all prescription, non-prescription, illegal, recreational, herbal and nutritional, or dietary drugs you are taking, especially:

  • Blood thinners such as warfarin (Coumadin)
  • Aspirin
  • Non-steroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn)
  • Corticotropin
  • Digoxin (Lanoxin)
  • Furosemide (Lasix)
  • Medications for diabetes, including insulin
  • Lithium (Eskalith, Lithobid)
  • Asthma or cold medications
  • Drugs for pain or seizures
  • Methenamine (Hiprex, Urex)
  • Other high blood pressure drugs
  • Sedatives

Metolazone side effects

Metolazone oral tablet doesn’t cause drowsiness. However, it can cause other side effects. Mild side effects may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

  • abdominal pain
  • blurred vision
  • constipation
  • diarrhea
  • dry mouth
  • headache

Metolazone warnings

Metolazone oral tablet comes with several warnings.

Allergy warning

Metolazone can cause a severe allergic reaction. Symptoms can include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Is metolazone safe to take if I'm pregnant or breastfeeding?

Metolazone should not be used during pregnancy unless absolutely necessary.

Metolazone is excreted in breast-milk. Intense diuresis using metolazone may reduce the production of milk. Otherwise metolazone is considered safe to use during nursing if required by the mother