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Methylprednisolone is used to treat conditions such as arthritis, blood disorders, severe allergic reactions, certain cancers, eye conditions, skin/kidney/intestinal/lung diseases, and immune system disorders. It decreases your immune system's response to various diseases to reduce symptoms such as swelling, pain, and allergic-type reactions. This medication is a corticosteroid hormone.

Methylprednisolone may also be used with other medications in hormone disorders.

Why it’s used

This drug is used to treat many conditions. It helps to control inflammation and to modify your body’s immune response. The conditions it’s used to treat include:

  • endocrine disorders such as primary or secondary adrenocortical insufficiency
  • rheumatic disorders such as rheumatoid arthritis or psoriatic arthritis
  • collagen diseases such as lupus or systemic dermatomyositis
  • skin diseases such as psoriasis or Stevens-Johnson syndrome
  • severe allergies that haven’t been controlled with other treatment, such as seasonal or year-round allergies or allergic reactions to medications
  • eye problems such as swelling or ulcers (sores) in your eye
  • stomach or intestinal problems such as ulcerative colitis or Crohn’s disease
  • respiratory problems such as lung damage caused by beryllium poisoning, or by Loeffler’s syndrome that’s not controlled by other treatments
  • blood disorders such as low levels of platelets in adults, or lack of red blood cells in children
  • neoplastic diseases such as blood cancer or cancer in the lymphatic system in adults
  • multiple sclerosis flare-ups
  • infections, such as trichinosis with brain or heart problems

Side Effects:

Important things to remember about the side effects of methylprednisolone include:

  • Most people do not experience all of the side effects listed.
  • Side effects are often predictable in terms of their onset and duration.
  • Side effects are almost always reversible and will go away after treatment is complete.
  • There are many options to help minimize or prevent side effects.

The following side effects are common (occurring in greater than 30%) for patients taking methylprednisolone:

  • Increased appetite
  • Irritability
  • Difficulty sleeping (insomnia)
  • Swelling in your ankles and feet (fluid retention)
  • Nausea, take with food
  • Heartburn
  • Muscle weakness
  • Impaired wound healing

Increased blood sugar levels. (Persons with Diabetes may need to have blood sugar levels monitored more closely and possible adjustments to diabetes medications).


Before taking methylprednisolone, tell your doctor or pharmacist if you are allergic to it; or to prednisone; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding problems, blood clots, brittle bones (osteoporosis), diabetes, eye diseases (such as cataracts, glaucoma, herpes infection of the eye), heart problems (such as recent heart attack, congestive heart failure), high blood pressure, current/past infections (such as those caused by tuberculosis, threadworm, herpes, fungus), kidney disease, liver disease, mental/mood conditions (such as psychosis, depression, anxiety), stomach/intestinal problems (such as diverticulitis, ulcer, ulcerative colitis), seizures.This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana.