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What Is Methylcobalamin?

Methylcobalamin is a type of vitamin B12. A vitamin is an organic substance the body needs in a tiny amount in order to function well. Vitamins are essential nutrients that the body cannot make on its own. So, you need to get vitamins from food and supplements. If you lack a vitamin or can’t absorb it because of a disease, you may become vitamin deficient. Vitamin deficiency can cause disease.

Methylcobalamin is a water-soluble vitamin. The body absorbs these vitamins easily and doesn’t store too much of them. The other type of vitamins are fat soluble, and the body can store them for use as needed.

What Is Vitamin B12 (Methylcobalamin)?

Vitamin B12 is the common name for a nutrient known scientifically as methylcobalamin.

It's used as a dietary supplement and to treat certain anemias.

Vitamin B12 plays an important role in helping the body make red blood cells.

Vitamin B12 Deficiency

If you have low levels of vitamin B12, you may feel weak, have less energy, and experience slow thinking -- a condition called pernicious anemia.

Other symptoms of pernicious anemia include numbness or tingling in the fingers and toes.

Your doctor will run blood tests to determine if your B12 levels are low.

People who eat a plant-based diet (vegans) are at greater risk because animal products often contain vitamin B12 naturally.

Older people are at higher risk of a vitamin B12 deficiency, too, because your body has a harder time absorbing the vitamin as you age.

Also, low levels of folic acid and low levels of vitamin B12 tend to go hand-in-hand.


If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Keep out of reach of children. Store at room temperature. Do not use if seal under cap is broken or missing. .


The safety of CNCbl has raised concerns due to the fact that cyanide is a component of CNCbl, and the cyanide molecule is removed from CNCbl when used by the body’s cells. Cyanide is also found in many fruits and vegetables and so humans are always ingesting small amounts of cyanide, and like in most fruits and vegetables, the amount of cyanide in CNCbl is considered to be physiologically insignificant.

For an analysis of the amount of cyanide in vitamin B12 supplements, see the table in Side Effects of B12 Supplements.


A 2015 paper by Obeid et al. suggests that people do not benefit more from the co-enzyme forms because all forms, except injected HOCbl, must have their side groups stripped by the target cell before the necessary side group is added for the co-enzyme form needed. People with genetic defects of vitamin B12 metabolism may benefit from HOCbl injections.

Currently, we do not have sufficient evidence to suggest that the benefits of using MeCbl or AdoCbl override that of using CNCbl or HOCbl in terms of bioavailability, biochemical effects, or clinical efficacy. There is uncertainty regarding the claimed superior role of [B12] coenzyme forms for prevention and treatment of [B12] deficiency. However, HOCbl may be an advantageous precursor of the cofactors, particularly in the inherited disorders of metabolic Cbl processing. CNCbl is a more stable and inexpensive form that appears to be best suited for oral supplementation and parenteral [intravenous] treatment as well.