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Memantine Side Effects

Memantine Side Effects

What is memantine?

Memantine is a prescription drug. It comes in three forms: immediate-release tablet, oral solution, and extended-release capsule.

Memantine oral tablet is available as the brand-name drug Namenda. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.

Memantine may be used as part of a combination therapy. That means you need to take it with other drugs to treat dementia associated with Alzheimer’s disease.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: carbonic anhydrase inhibitors (such as acetazolamide, methazolamide), sodium bicarbonate.

How it works

Memantine belongs to a class of drugs called NMDA receptor antagonists. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

The cause of Alzheimer’s disease isn’t fully understood. People with the disease may be overexposed to the chemical glutamate. This is thought to cause damage to the brain cells in people with Alzheimer’s disease.

Memantine works by blocking the receptors in the brain that glutamate would normally bind to. This decreases the harmful effect of glutamate in the brain and may help improve your symptoms of dementia.

Precautions

Before taking this product, tell your doctor or pharmacist if you are allergic to memantine; or to donepezil; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, severe urinary tract infections, recent dietary change (from a high-protein diet to a vegetarian diet), stomach/intestinal disease (such as bleeding, ulcers), difficulty urinating (such as due to enlarged prostate), seizures, breathing problems (such as asthma, chronic obstructive pulmonary disease-COPD).

Donepezil may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using this product, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Storage

Keep this drug at a temperature between 59°F and 77°F (15°C and 25°C).

Keep this drug away from light and high temperature.

Don’t store this medication in moist or damp areas, such as bathrooms.

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