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Meclizine HCl + Caffeine

Meclizine HCl + Caffeine

What is meclizine?

Meclizine is a prescription drug that only comes as an oral tablet.

Meclizine oral tablet is only available as a generic drug. It doesn't have a brand-name version.

Why it's used

Meclizine oral tablet is used to treat vertigo (feeling like you or the room is spinning).

Meclizine may be used as part of a combination therapy. This means you may need to take it with other drugs.

How it works

Meclizine belongs to a class of drugs called antihistamines. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. Meclizine works in your brain. It works by blocking chemicals that control nausea, vomiting, and balance.

About Meclizine

First Generation H1 Antagonist, Piperazine derivative, Antihistamine, antiemetic, antinauseant.

Mechanism of Action of Meclizine

Meclizine produces Antiemetic action by its central action on Chemoreceptor trigger zone (CTZ). It decreases the sensitivity of Labyrinth apparatus which transmit stimuli to the CTZ and stimulates the vomiting center.

Meclizine produces antivertigo action by decreasing the excitability of middle ear labyrinth. It blocks the conduction in the middle ear vestibular path ways.

Meclizine is a potent H1 receptor antihistaminic agent. It has anticholinergic activity also


For the treatment of vertigo associated with diseases affecting the vestibular system, the recommended dose is 25 to 100 mg daily, in divided dosage, depending upon clinical response.

Side Effects

Drowsiness, dry mouth, and tiredness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.

If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as restlessness, confusion), fast/irregular heartbeat, shaking (tremor), difficulty urinating.

Warnings for other groups

For pregnant women: Meclizine is a category B pregnancy drug. That means two things:

  • Research in animals hasn't shown a risk to the fetus when the mother takes the drug.
  • There aren't enough studies done in humans to show if the drug poses a risk to the fetus.

Talk to your doctor if you're pregnant or planning to become pregnant. Animal studies don't always predict the way humans would respond. Therefore, this drug should only be used in pregnancy if clearly needed.


Before taking meclizine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as asthma, emphysema), high pressure in the eye (glaucoma), heart problems, high blood pressure, seizures, stomach/intestine problems (such as ulcers, blockage), overactive thyroid (hyperthyroidism), difficulty urinating (for example, due to enlarged prostate), liver problems, kidney problems.

This drug may make you drowsy. Alcohol or marijuana can make you more drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana.