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Maximum Dose of Glipizide

Maximum Dose of Glipizide


Glipizide is a prescription medication used to treat type 2 diabetes. Glipizide belongs to a group of drugs called sulfonylureas, which help lower blood sugar levels by causing the pancreas to secrete insulin.

This medication comes in regular tablet and extended release tablet forms. The regular tablet is taken one or more times a day before meals. The extended-release tablet is taken once a day with breakfast.

Common side effects of glipizide include nausea, diarrhea, and gas. Glipizide can cause dizziness. Do not drive or operate machinery until you know how glipizide affects you.

How it works

Glipizide belongs to a class of drugs called sulfonylureas. A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.

Glipizide helps release insulin from your pancreas. Insulin moves sugar from your bloodstream to your cells, where it belongs. This decreases your blood sugar levels.

Side effects

  • nausea
  • diarrhea
  • gas
  • weakness
  • nervousness
  • headache
  • shakiness
  • dizziness

Glipizide Interactions

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin (Ecotrin), ibuprofen (Advil), naproxen (Aleve, Naprosyn), and others
  • azoles, such as miconazole (Lotrimin and Monistat) and fluconazole (Diflucan)
  • salicylic acid containing products, such as Pepto-Bismol
  • chloramphenicol (Chloromycetin)
  • probenecid (Probalan)
  • anticoagulants, or "blood thinners", such as warfarin (Coumadin, Jantoven)
  • monoamine oxidase (MAO) inhibitors, such as selegiline (Emsam), phenelzine (Nardil), and others

Glipizide Precautions

Glipizide may increase your chance of death from heart disease.Glipizide can cause low blood sugar levels (hypoglycemia) in patients. Tell your doctor if you have a history of kidney or liver disease or drink alcohol.After exposure to stress, such as fever, trauma, infection, or surgery, glipizide may cause you to lose control over your blood glucose levels. Glipizide can decrease the number of red blood cells in people with glucose-6-phosphate dehydrogenase (G6PD) deficiency.  Alert your doctor if you have a history of G6PD deficiency or anemia.

Glipizide warnings

This drug comes with several warnings.

Fatal heart problems warning

Glipizide raises your risk of fatal heart problems compared to treatment with diet alone or diet plus insulin. Ask your doctor if glipizide is right for you.

Diabetic ketoacidosis warning

Don’t use this medication to treat diabetic ketoacidosis, a serious medical condition whose complications can include coma. This condition must be treated with insulin.

Low blood sugar warning

Glipizide can cause low blood sugar (hypoglycemia). If you don’t treat low blood sugar, you can have a seizure, pass out, and possibly develop brain damage. Low blood sugar can even be fatal.

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