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Lopinavir and Ritonavir

Lopinavir and Ritonavir

About Lopinavir and Ritonavir

Ritonavir is used along with other medications to treat human immunodeficiency virus (HIV) infection. Ritonavir is in a class of medications called protease inhibitors. It works by decreasing the amount of HIV in the blood. Although ritonavir does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other lifestyle changes may decrease the risk of transmitting the HIV virus to other people.

What is the dosage for ritonavir?

The recommended dose for adults is 600 mg twice daily. To reduce the occurrence of side effects, ritonavir should be started at 300 mg twice daily and increased every 2-3 days by 100 mg twice daily.

The recommended dose for children older than 1 month is 350 to 400 mg/m2 two times a day and should not exceed 600 mg two times daily. Treatment should be started at 250 mg/m2 and increased every 2-3 days by 50 mg/m2 two times daily.

How should I take ritonavir?

Ritonavir (brand name: Norvir) comes in the following forms and strengths:

  • 100-mg tablets.
  • 100-mg soft gelatin capsules.
  • 80-mg/mL oral solution. (An oral solution is a mixture of a medicine and a liquid that can be taken by mouth.)
  • 100-mg of oral powder (The oral powder is mixed with soft foods or liquid and then can be taken by mouth.)

Take ritonavir according to your health care provider’s instructions.

Uses

This drug is used with other HIV medications to help control HIV infection. It helps to decrease the amount of HIV in your body so your immune system can work better. This lowers your chance of getting HIV complications (such as new infections, cancer) and improves your quality of life.

Ritonavir belongs to a class of drugs known as protease inhibitors. It increases ("boosts") the levels of other protease inhibitors, which helps these medications work better.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Ritonavir interacts with many medications. Some products that may interact with this drug include: cobicistat, disulfiram, orlistat.

How should I keep ritonavir stored?

Capsules that will not be used within 30 days should be stored in a refrigerator between 2 C to 8 C (36 F to 46F). Capsules that will be used within 30 days do not have to be refrigerated if stored at less than 25 C (77 F) Oral solution should be stored at room temperature, 20 C to 25 C (68 F to77 F).

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