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About Loperamide

While elements of the high obtained from loperamide resemble that of an opioid high, there are distinct differences. Pharmacist and clinical toxicologist William Eggleston noted these differences in a recent Newsweek article, explaining, “Anecdotally, the high is a little bit different in that it doesn’t give you the same head rush that heroin gives you.” And as user on Bluelight, an online forum dedicated to discussions about drug use, indicates, overdosing to get a loperamide high is “not worth the health risks, whatever they are.”

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Eliglustat
  • Saquinavir
  • Simeprevir

Side Effects

Dizziness, drowsiness, tiredness, or constipation may occur. If any of these effects persist or worsen, contact your doctor promptly.

If your doctor has prescribed this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.


Loperamide should not be used for more than 2 days, unless directed by your doctor. If you will be taking this medicine regularly for a long time, your doctor should check your progress at regular visits.

Check with your doctor if your diarrhea does not stop after two days or if you develop a fever