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letrozole weight gain

letrozole weight gain

What Is Letrozole?

Letrozole is an aromatase inhibitor which prevents the conversion of androgen to estrogen. It also improves endometrial thickness and encourages healthy ovarian follicular development. While not approved by the FDA for this use, it has been shown to induce ovulation in women who do not ovulate. For this reason, some infertility specialists are using the drug in women who cannot tolerate or who do not respond well to Clomid.

Letrozole is a drug that is commonly used to treat estrogen-dependent tumors, particularly breast cancer in older, post-menopausal women.

Dosing

Letrozole comes in 2.5mg tablets and is taken once a day for 5 days, usually beginning on day three or day five of your menstrual cycle. You may need monitoring through blood tests and/or ultrasounds to determine when you are approaching ovulation.

What Might Cause Me to Gain Weight?

Chemotherapy can bring on premature menopause. And with it comes a slowing of the metabolism. That makes it harder to keep weight off. Menopause also causes you to gain more body fat and lose lean muscle.

It’s common for women who have chemotherapy to gain about 5 to 14 pounds over a year. Some gain less, while others put on as many as 25 pounds.

Another reason for weight gain is the use of corticosteroids. These medications help with nausea and swelling, or to stop reactions to chemotherapy. These drugs can boost your appetite. Corticosteroids are hormones that can also cause an increase in fatty tissue. They can make you lose muscle mass in your arms and legs, and gain belly fat, too. You may also have a fullness of the neck or face. Loss of muscle makes weight gain more apparent.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Feeling tired or weak.
  • Hot flashes.
  • Headache.
  • Dizziness.
  • Upset stomach or throwing up.
  • Cough.
  • Back pain.
  • Muscle or joint pain.
  • Constipation.
  • Loose stools (diarrhea).

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

Risks of Birth Defects:

It is important to note that this medication is incompatible with pregnancy and breastfeeding. However, please understand that you are taking this drug before you become pregnant, so it does not increase your risk of having a child with birth defects. Letrozole should be stopped as soon as pregnancy is achieved.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

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