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letrozole reviews

letrozole reviews

What is Letrozole (Femara)?

Letrozole, sold under the brand name Femara, is a prescription drug used to treat breast cancer in its advanced stages, and in women who have finished menopause.

Doctors may use letrozole off-label in fertility treatments to help encourage egg release (ovulation) in women.

Letrozole belongs to a class of cancer drugs known as aromatase inhibitors, which work by preventing the body from converting a hormone called androgen into estrogen.

Letrozole Warnings

You shouldn't take letrozole if you:

  • Are allergic to letrozole or any of its active or inactive ingredients
  • Are pregnant
  • Have not yet entered menopause
  • Have liver problems

Ask your doctor about letrozole if you have glaucoma or other issues with increased pressure in the eye.

User Reviews for Letrozole

  • "I have been on this drug for over a year now. This is my update to a previous comment. I stopped it on the advice of my doctor, because of my hot flashes & sweats, joint pain. It was a month break. Started it up again, my hot flashes & sweats, were subsiding, now they are getting worse again. My joint pain is going away. Some nights I may sleep 4 hours max."
  • For Breast Cancer: "I had stage 2 Hers 2 positive breast cancer. Did 5 rounds of Chemo that made me so sick. Heavy bouts of diarrhea almost constantly and lost 20 lbs after 2 months of radiation everyday. In 2015 I started letrazole and at first it was nothing, now I feel so much joint pain in the early morning and then at night. I feel like I got hit by a truck. Stairs are unbelievably hard to master during this time. I’ve gained at least 20 lbs which is hard to believe because I eat small portions. I have mentioned this to my oncologist team and they don’t believe weight is a side affect. Wrong! It is most definitely. 2 more years to go, hopefully there’s some improvements. I will take magnesium as suggested, we’ll see."
  • I have just been on for a week. I use to be on Arimdex but hot flashes became so severe I had to stop it. I decided not to take anything for a couple of y ears and now doctor said try this one. I did find out by my radiation doctor that if I take magnesium OTC every day that would stop hot flashes. She was right from day one they stopped it. I took 250 mgs a day every week for a month and the

Letrozole Side Effects

Common Side Effects of Letrozole

You should tell your doctor if any of the following side effects are severe or don't go away:

  • Bone, joint, and/or muscle pain
  • Headache and nausea
  • Sweating, cough
  • Constipation
  • Trouble breathing
  • Trouble sleeping
  • Weight gain
  • High cholesterol
  • Altered liver function tests
  • Depression
  • Hair loss or baldness
  • Swelling of the feet, ankles, and lower legs


You should tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking.

Don't take letrozole if you're taking the following drugs:

  • The supplement DHEA
  • Birth control pills, or hormone replacement therapy that contains estrogen
  • Norinyl 1 50 28-day (mestranol)
  • Soltamox (tamoxifen)

Letrozole Dosage

Letrozole comes in tablets of 2.5 milligrams (mg).

How much letrozole your doctor tells you to take may vary, but for cancer, a usual dose is 2.5 mg a day.

If you're taking letrozole for fertility treatment, your doctor may tell you to take either 2.5 mg or 5 mg of the drug, beginning on the third day of your period for five days.

Letrozole Overdose

If you think you might've overdosed on letrozole, contact an emergency room at 911 or a poison control center 800-222-1222 right away.

Missed Dose of Letrozole

If you miss a dose of letrozole, try to take it as soon as you remember.

However, if it's almost time for your next dose, skip the missed dose and continue on your regular dosing schedule.

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