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letrozole pcos

What Is Letrozole?

letrozole pcos is an aromatase inhibitor which prevents the conversion of androgen to estrogen. It also improves endometrial thickness and encourages healthy ovarian follicular development. While not approved by the FDA for this use, it has been shown to induce ovulation in women who do not ovulate. For this reason, some infertility specialists are using the drug in women who cannot tolerate or who do not respond well to Clomid.

Letrozole is a drug that is commonly used to treat estrogen-dependent tumors, particularly breast cancer in older, post-menopausal women.

How to Use letrozole pcos

letrozole pcos is offered in 2.5-milligram yellow, film-coated tablet. Based on when your period begins, your doctor will advise you when to start treatment. Treatment will be taken over five consecutive days.

Some fertility experts recommend taking the pills on days 3, 4, 5, 6 and 7 of your cycle. Others endorse days 5, 6, 7, 8, and 9. While there remains debate on which option is truly best, current research seems to suggest that success rates are more-or-less the same.

What is the treatment for PCOS and infertility?

Polycystic ovarian syndrome is a common cause of female infertility. The ovaries in these women contain multiple small cystic structures, or antral follicles, that are 2-9 mm in diameter.

Side Effects

letrozole pcos works by reducing estrogen levels in order to stimulate ovulation. Low estrogen levels of any sort can cause a woman to have symptoms. Those most commonly seen with letrozole pcos use include:

  • Fatigue
  • Dizziness
  • Headache
  • Bloating
  • Hot flashes
  • Night Sweats
  • Blurred vision
  • Upset stomach
  • Breast pain
  • Difficulty sleeping
  • Spotting or unusual menstrual bleeding


letrozole pcos  comes in 2.5mg tablets and is taken once a day for 5 days, usually beginning on day three or day five of your menstrual cycle. You may need monitoring through blood tests and/or ultrasounds to determine when you are approaching ovulation.

Oral dosage

Adult premenopausal females

Limited studies indicate that 2.5 mg, 5 mg, or 7.5 mg PO once daily for 5 days, typically given on days 3 through 7 of the menstrual cycle, may be effective; in a study comparing 2.5 mg letrozole (n = 34) to 5 mg letrozole (n = 38) PO daily for 5 days, pregnancy rates per cycle were significantly higher in patients


Letrozole also appears beneficial in couples with unexplained infertility. Compared with clomiphene, it is associated with a higher pregnancy rate, lower estradiol levels, fewer follicles, thicker endometrium and better endometrial blood flow as observed on Doppler ultrasound.[13] Increasing the dose of letrozole to 7.5 mg appears to be unnecessary.



Store at controlled room temperature (between 68 and 77 degrees F)

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