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letrozole ovulation


The drug is used as a first-line treatment for women with polycystic ovary syndrome (PCOS), a condition where they ovulate irregularly or don’t ovulate at all, and most other ovulatory disorders, says Clifford Librach, director of the Create Fertility Centre in Toronto and president-elect of the Canadian Fertility and Andrology Society. It can also be used to treat unexplained infertility.

How does letrozole ovulation work?

Letrozole is typically taken once a day for five days. When you take the drug, it stops androgens in your body from converting into estrogen. When estrogen is blocked, the pituitary gland gets a message that it needs to produce follicle-stimulating hormone (FSH), which stimulates the ovary to produce an egg. Some women on letrozole actually release more than one egg because they produce more FSH while on letrozole than a woman produces when ovulating naturally.

How effective is letrozole ovulation ?

Togas Tulandi, a reproductive endocrinology and infertility specialist and chief of the obstetrics and gynaecology department at the McGill University Health Centre in Montreal, says that letrozole has a decent rate of inducing ovulation. The same 2014 study from the New England Journal of Medicine showed that, among participants with PCOS who used letrozole, 27.5 percent got pregnant within five cycles and went on to have live births. The study also found that the drug induced ovulation in 61.7 percent of women with PCOS.

How are Femara and letrozole ovulation  Used as a Fertility Drug?

Femara to Induce Ovulation

When the enzyme aromatase is inhibited by the letrozole medication, estrogen levels are suppressed in young women. This results in the brain and pituitary gland increasing the output of FSH (follicle stimulating hormone).

In women that have polycystic ovary syndrome or anovulation (a problem with ovulation) the increase in FSH hormone can result in development of a mature follicle in the ovary and ovulation of an egg. Doctors call this process "induction of ovulation".

Effectiveness of letrozole ovulation

There is increasing evidence that letrozole ovulation may be more suitable for women with PCOS suffering from ovulation problem.

According to a 2014 study published in the New England Journal of Medicine, 27.5 percent women with PCOS who took letrozole ovulation had a successful birth compared to 19.5 percent who took Clomid. The same study demonstrated advantages in several other areas:

The ovulation rate was higher with Femara (61.7 percent) compared to Clomid (48.3 percent).

There was a higher birth rate among obese women with PCOS who used Femara.

Side Effects

letrozole ovulation works by reducing estrogen levels in order to stimulate ovulation. Low estrogen levels of any sort can cause a woman to have symptoms. Those most commonly seen with letrozole ovulation use include:

  • Fatigue
  • Dizziness
  • Headache
  • Bloating
  • Hot flashes
  • Night Sweats
  • Blurred vision
  • Upset stomach
  • Breast pain
  • Difficulty sleeping
  • Spotting or unusual menstrual bleeding

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose. Take your next dose at the regular time. Do not double the dose to catch up.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.Information last revised June 2018. Copyright(c) 2018 First Databank, Inc.


letrozole ovulation has been shown to be an efficient and effective agent in inducing both ovulation and superovulation. There has been debate as to the optimal starting dose of letrozole. The 5mg-daily yields higher clinical PRs (p<0.05) than 7.5mg. In addition, this group had a lower prevalence of multiple PR and miscarriage rates (p=NS). To strengthen these findings, a randomized trial in cohorts of patients of diverse diagnoses that investigates a range of LET start and total dosages would enhance individualized clinical application.

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