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Lamivudine and Tenofovir

Lamivudine and Tenofovir

What is tenofovir disoproxil fumarate?

Tenofovir DF is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 2 years of age and older. Tenofovir DF is always used in combination with other HIV medicines.

Tenofovir DF belongs to a class (group) of HIV drugs called nucleoside reverse transcriptase inhibitors (NRTIs). NRTIs block an HIV enzyme called reverse transcriptase. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking reverse transcriptase, NRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body.

HIV medicines can't cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission. If you are taking HIV medicines, including tenofovir DF, don't cut down on, skip, or stop taking them unless your health care provider tells you to.

Tenofovir DF is also approved by FDA for the treatment of chronic hepatitis B virus (HBV) infection in adults and children 12 years of age and older. For information on the HBV-related use of tenofovir DF in people with HIV, please refer to the HBV section of the Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents.

Why is this medication prescribed?

The combination of efavirenz, lamivudine, and tenofovir is used to treat HIV in adults and children. Efavirenz is in a class of medications called non-nucleoside reverse transcriptase inhibitors (NNRTIs). Lamivudine and tenofovir are in a class of medications called nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs). They work by decreasing the amount of HIV in the body. Although efavirenz, lamivudine and tenofovir will not cure HIV, these medications may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other lifestyle changes may decrease the risk of getting or transmitting the HIV virus to other people.

How should this medicine be used?

The combination of efavirenz, lamivudine, and tenofovir comes as a tablet to take by mouth. It is usually taken once a day on an empty stomach (at least 1 hour before or 2 hours after a meal). Take efavirenz, lamivudine, and tenofovir at around the same time every day. Taking efavirenz, lamivudine, and tenofovir at bedtime may make certain side effects less bothersome. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take efavirenz, lamivudine, and tenofovir exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Continue to take efavirenz, lamivudine, and tenofovir even if you feel well. Do not stop taking efavirenz, lamivudine, and tenofovir without talking to your doctor. If you stop taking efavirenz, lamivudine, and tenofovir even for a short time, or skip doses, the virus may become resistant to medications and may be harder to treat.

HIV Infection

Indicated in combination with other antiretroviral agents for HIV-1 infection

Combination consists of 2 nucleo(t)side reverse transcriptase inhibitors (NRTIs) (ie, lamivudine and tenofovir)

1 tablet (lamivudine 300 mg/tenofovir 300 mg) PO qDay in combination with other ARTs

Also see administration

Side Effects

Dizziness, headache, diarrhea, nausea, or trouble sleeping may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Precautions

Before taking this medication, tell your doctor or pharmacist if you are allergic to lamivudine or tenofovir; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

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