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Lacosamide

Lacosamide

Description

Lacosamide is a functionalized amino acid that has activity in the maximal electroshock seizure test, and is indicated for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Recent studies indicate that Lacosamide only affects those neurons which are depolarized or active for long periods of time, typical of neurons at the focus of an epileptic seizure, as opposed to other antiepileptic drugs such as carbamazepine or lamotrigine which slow the recovery from inactivation and reduce the ability of neurons to fire action potentials.

Used to treat

  • Temporal Lobe Epilepsy
  • Focal Impaired Awareness or Complex Partial Seizures
  • Secondarily Generalized Seizures or Bilateral Tonic Clonic Seizure
  • Focal Aware or Simple Partial Seizure

What is VIMPAT?

VIMPAT is a prescription medicine used to treat partial-onset seizures in people 4 years of age and older.

It is not known if VIMPAT injection is safe for use in children. Children age 4 years and older should only take VIMPAT by mouth. VIMPAT injection is only for use in people 17 years of age and older.

It is not known if VIMPAT is safe and effective in children under 4 years of age.

How does Lacosamide affect the brain?

Brain cells work and talk to each other by generating electrical discharges. These discharges must be sent or fire at a certain rate to function normally. Sodium channels are like gates in brain cells - they help to spread electrical activity from one cell to another.

Most seizure medicines slow down the electrical discharges in some way.

Lacosamide may help to slow down or turn off sodium channels in the brain. This may help stop a seizure and allow brain cells to recover.

Why is this medication prescribed?

Lacosamide is used in combination with other medications to control certain types of seizures. Lacosamide is in a class of medications called anticonvulsants. It works by decreasing abnormal electrical activity in the brain.

How should this medicine be used?

Lacosamide comes as a tablet to take by mouth. It is usually taken twice a day (morning and night) with or without food. Take lacosamide at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lacosamide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

What are the most common side effects of Lacosamide?

Th most common side effects include:

  • Coordination problems
  • Dizziness
  • Double vision
  • Headache
  • Nausea, vomiting
  • Sleepiness
  • Unsteady walking

Problems with coordination and walking usually get better over a few weeks. Tell your provider if the problems continue.

What are the dose ranges for Lacosamide?

The best amount of seizure medicine is the amount that controls seizures without causing bothersome side effects. This depends on many factors, which are different for every person.

  • The approved dose range of lacosamide for adults is 200 to 400 mg daily.
  • When used as the only seizure medicine, the lowest recommended dose is 300 mg.
  • Lower doses may be used if people have side effects or the amount may be increased more slowly.
  • Higher doses may be needed in some people as well, though higher doses may cause more side effects.
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