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Isosorbide Dinitrate

Isosorbide Dinitrate

About Isosorbide Dinitrate

Isosorbide dinitrate (ISDN) is a medication used for heart failure, esophageal spasms, and to treat and prevent chest pain from not enough blood flow to the heart. It has been found to be particularly useful in heart failure due to systolic dysfunction together with hydralazine in black people.

How should I take isosorbide dinitrate?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication. Isosorbide dinitrate is usually taken 2 or 3 times per day. Follow your doctor's dosing instructions very carefully.

If possible, try to rest or stay seated when you use this medication. Isosorbide dinitrate can cause dizziness or fainting.

nocrush                Do not crush, chew, break, or open an extended-release tablet or capsule. Swallow the pill whole. Breaking the pill may cause too much of the drug to be released at one time.

How to use Isosorbide Dinitrate Tablet

Take this medication by mouth, usually once or twice daily or as directed by your doctor. If you are using this medication twice daily, take the first dose of the day when you wake up, then take the second dose 6 to 7 hours later. It is important to take the drug at the same times each day. Do not change the dosing times unless directed by your doctor.


Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Side Effects

Headache, dizziness, lightheadedness, nausea, and flushing may occur as your body adjusts to the medication. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Isosorbide Dinitrate Interactions

Tell your doctor and pharmacist about all prescription, over-the-counter, illegal, recreational, herbal, nutritional, or vitamin-containing drugs and supplements you're taking.

Don't take isosorbide dinitrate if you're taking any of the following drugs:

  • Adempas (riociguat)
  • Any drug for erectile dysfunction, like Adcirca or Cialis (tadalafil), Staxyn or Levitra (vardenafil), Stendra (avanafil), and Viagra (sildenafil).

Isosorbide Dinitrate Warnings

You shouldn't take isosorbide if you're allergic to the drug, nor should you take any drug that contains isosorbide (such as BiDil), or the closely related isosorbide mononitrate (Monoket, Ismo, and Imdur).

You should also avoid these drugs if you're allergic to any of the ingredients they contain.

Talk to your doctor before taking isosorbide dinitrate if you:

  • Have low blood pressure
  • Recently had a heart attack
  • Have congestive heart failure
  • Have a condition that causes the walls of your heart to thicken

Are dehydrated