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Ipratorium Bromide - Salbutamol Sulphate

DESCRIPTION

COMBIVENT Inhalation Aerosol is a combination of ipratropium bromide (as the monohydrate) and albuterol sulfate.

Ipratropium bromide is an anticholinergic bronchodilator chemically described as 8-azoniabicyclo[3.2.1] octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl8-(1-methylethyl)-, bromide monohydrate, (3-endo, 8-syn)-: a synthetic quaternary ammonium compound chemically related to atropine. Ipratropium bromide is a white to off-white crystalline substance, freely soluble in water and methanol, sparingly soluble in ethanol, and insoluble in lipophilic solvents such as ether, chloroform, and fluorocarbons.

How does it work?

Combivent UDVs contain two active ingredients, ipratropium bromide and salbutamol sulphate, both of which are bronchodilators. Combivent UDVs are used to treat people suffering from chronic obstructive pulmonary disease, who require regular treatment with ipratropium and salbutamol.

Salbutamol belongs to a group of medicines called short-acting beta 2 agonists. It works by acting on receptors in the lungs called beta 2 receptors. Stimulation of these receptors causes the muscles in the airways to relax, allowing the airways to open.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

Common (affect between 1 in 10 and 1 in 100 people)

  • Dry mouth.

Uncommon (affect between 1 in 100 and 1 in 1000 people)

  • Headache.
  • Difficulty in passing urine (urinary retention).
  • Dizziness.
  • Shaking, usually of the hands (tremor).
  • Nervousness.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Pregnancy and breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

This medicine should be used with caution during pregnancy, and only if the expected benefit to the mother is greater than the possible risk to the foetus, particularly in the first trimester. Seek medical advice from your doctor.

This medicine should be used with caution by breastfeeding mothers, and only if the expected benefit to the mother is greater than any possible risk to the baby. Seek medical advice from your doctor.

Warnings/Precautions:

Not for primary treatment of acute attack. Avoid excessive use. Discontinue if paradoxical bronchospasm or cardiovascular effects occur. Cardiovascular disease (eg, coronary insufficiency, arrhythmias, hypertension). Hyperthyroidism. Diabetes. Seizure disorders. Narrow angle glaucoma. GI or GU obstruction. Hepatic or renal disease. Avoid eyes. Pregnancy (Cat.C). Labor & delivery. Nursing mothers: not recommended.

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