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Imipenem+ Cilastatin

Imipenem+ Cilastatin

What is imipenem and cilastatin?

Imipenem is an antibiotic that fights bacteria.

Cilastatin helps imipenem work more effectively by preventing the breakdown of the antibiotic in the kidneys.

Imipenem and cilastatin is a combination medicine used to treat severe infections of the lower respiratory tract, skin, stomach, or female reproductive organs.

Imipenem and cilastatin may also be used for purposes not listed in this medication guide.


This medication is used to treat a wide variety of bacterial infections. This medication is known as a carbapenem-type antibiotic. It works by stopping the growth of bacteria.

How to use Imipenem-Cilastatin SODIUM Vial

This medication is given by injection into a muscle or vein, usually every 6 to 8 hours or as directed by your doctor. The dosage is based on your medical condition and response to treatment.

If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.

Common side effects may include:

  • pain where the medicine was injected
  • dizziness, drowsiness
  • nausea, vomiting, diarrhea
  • itching, rash
  • swollen tongue

Dosage In Adults

For Intravenous Injection Only

The dosage of PRIMAXIN in adult patients should be based on suspected or confirmed pathogen susceptibility as shown in Table 1 below. The dosage recommendations for PRIMAXIN represent the quantity of imipenem to be administered. An equivalent amount of cilastatin is also present in the solution.

These doses should be used for patients with creatinine clearance of greater than or equal to 90 mL/min. A reduction in dose must be made for patients with creatinine clearance less than 90 mL/min as shown in Table 3 [see Dosage in Adult Patients with Renal Impairment].

Recommend that the maximum total daily dosage not exceed 4 g/day.

Administer 500 mg by intravenous infusion over 20 to 30 minutes.

Administer 1000 mg by intravenous infusion over 40 to 60 minutes.

Storage Of Reconstituted Solutions

PRIMAXIN, as supplied in single dose vials and reconstituted with the appropriate diluents [see Reconstitution and Preparation of PRIMAXIN Solution for Intravenous Administration], maintains satisfactory potency for 4 hours at room temperature or for 24 hours under refrigeration (5°C). Do not freeze solutions of PRIMAXIN.

The dry powder should be stored at a temperature below 25°C (77°F).