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Hydroxyurea Side Effects Long Term

hydroxyurea side effects long term

What is hydroxyurea side effects long term?

hydroxyurea side effects long termis a prescription drug. It comes in two forms: a capsule and a tablet. You take both forms by mouth.

Hydroxyurea oral capsule is available as the brand-name drugs Hydrea and Droxia. Hydrea is also available as a generic drug. Droxia is not. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.

Hydroxyurea may be used as part of a combination therapy. This means you may need to take it with other medications.

Why it's used

hydroxyurea side effects long term is used to treat myeloid leukemia and head and neck cancers. It prevents cancer cells from growing. It’s also used to treat sickle cell disease.

How to take hydroxyurea

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

Common side effects may include:

  • bleeding;
  • loss of appetite, upset stomach, constipation, diarrhea, vomiting;
  • skin peeling or itching, mild rash;
  • hair loss, darkening of your nails;
  • headache, dizziness; or.
  • swelling in your hands or feet.

side effects can this medication cause?

  • Hydroxyurea may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
  • nausea
  • vomiting
  • diarrhea
  • loss of appetite
  • weight gain
  • sores in the mouth and throat
  • constipation
  • rash
  • pale skin
  • dizziness
  • headache
  • hair loss
  • changes in skin and nails

Efficacy and safety of long-term use of hydroxyurea in young patients with essential thrombocythemia and a high risk of thrombosis

The optimal treatment of young patients with essential thrombocythemia (ET) at high risk of thrombohemorrhagic complications is uncertain. Storen and Tefferi1 recently reported on the long-term use of anagrelide, a platelet-lowering agent without myelosuppressive activity. In a population of 35 young ET patients (median age, 38 years; range, 17-48 years) followed for a median of 10.8 years (range, 7-15 years), rates of 20% for thrombosis, 20% for major bleeding, and 24% for anemia were observed. Hydroxyurea (HU) may be a more effective agent, because a significant reduction in the incidence of thrombotic complications was demonstrated in a randomized clinical trial including ET patients of all ages.      


hydroxyurea side effects long term contains a black-box warning because it can cause a severe drop in the number of blood cells in your bone marrow. This can increase your risk of a serious infection or bleeding.

Tell your doctor right away if you experience any of the following symptoms while taking hydroxyurea:

  • Fever, sore throat, cough, congestion, or other signs of infection
  • Unusual bruising or bleeding
  • Vomit that's bloody or looks like coffee grounds
  • Bloody or black, tarry stools

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

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