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Human Insulin Regular - Human Insuline Isophane

Human Insulin Regular - Human Insuline Isophane


Combination isophane/regular insulin is used with a proper diet and exercise program to control high blood sugar in people with diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke.

This man-made insulin product is the same as human insulin. It replaces the insulin that your body would normally make. It is a mixture of 70% intermediate-acting insulin (isophane) and 30% short-acting insulin (regular). It starts to work as quickly as regular insulin but lasts longer.

What happens if I miss a dose?

Since this medicine is used with a meal, you may not be on a timed dosing schedule. Whenever you use this insulin, be sure to eat a meal within 45 minutes. Do not use extra medicine to make up a missed dose.

Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Insulin overdose can cause life-threatening hypoglycemia. Symptoms include drowsiness, confusion, blurred vision, numbness or tingling in your mouth, trouble speaking, muscle weakness, clumsy or jerky movements, seizure (convulsions), or loss of consciousness.

What is insulin isophane and insulin regular?

Insulin isophane and insulin regular is a man-made form of a hormone that is produced in the body. It works by lowering levels of glucose (sugar) in the blood. Insulin isophane and insulin regular is a long-acting form of insulin that is slightly different from other forms of insulin that are not man-made.

Insulin isophane and insulin regular is used to treat diabetes.Insulin isophane and insulin regular may also be used for other purposes not listed in this medication guide.


Insulin requirements may be increased if you are taking other drugs with blood-glucose-raising activity, such as oral contraceptives, corticosteroids, or thyroid replacement therapy. Insulin requirements may be reduced in the presence of drugs that lower blood glucose or affect how your body responds to insulin, such as oral antidiabetic agents, salicylates (for example, aspirin), sulfa antibiotics, alcohol, certain antidepressants and some kidney and blood pressure medicines.


Your Healthcare Professional may be aware of other medications that may affect your diabetes control. Therefore, always discuss any medications you are taking with your doctor.


Administer within 15 min before a meal or immediately after a meal

Store unopened vials/pens refrigerated; do not freeze

Opened (in-use) product may be stored at ambient room temperature (below 86°F [30°C]) and away from heat and light

Dosage Adjustment Strategies

Dosage of human insulin, which is always expressed in USP units, must be based on the results of blood and urine glucose tests and must be carefully individualized to optimal effect

  • Dose adjustments should be based on regular blood glucose testing (See Dosage Adjustment Strategies)
  • Adjust to achieve appropriate glucose control
  • Look for consistent pattern in blood sugars for >3 days
  • Compare blood glucose for same time each day
  • For each time of day: calculate blood glucose range
  • Calculate median blood glucose
  • Consider eating and activity patterns during day


Before using combination isophane/regular insulin, tell your doctor or pharmacist if you are allergic to it; or to other types of insulins; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Do not use this medication when you have low blood sugar (hypoglycemia).