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Glimepiride Amaryl

glimepiride amaryl

What is Amaryl?

Amaryl (glimepiride) is an oral diabetes medicine that helps control blood sugar levels. Amaryl is used together with diet and exercise to treat type 2 diabetes. Insulin or other diabetes medicines are sometimes used in combination with Amaryl if needed. Amaryl may also be used for purposes not listed in this medication guide.

Mechanism of action

Amaryl helps reduce the amount of glucose in your blood by stimulating the release of insulin from the pancreas into the blood and encouraging the use of sugar in your blood by the cells that need it.

How does this medication work? What will it do for me?

Glimepiride belongs to a group of medications known as oral hypoglycemics. It is used to control blood sugar for people with type 2 diabetes. It is used when diet, exercise, and weight reduction have not been found to control blood sugar well enough on their own. Glimepiride increases the amount of insulin released by the pancreas and helps the body use insulin more efficiently.

Glimepiride may be used in combination with metformin or insulin when diet and exercise and the use of these medications on their own do not provide adequate control of blood sugar.

How and when to take Amaryl

Amaryl tablets are available in 1mg, 2mg, 3mg and 4mg doses. Normally a single daily dose of glimepiride is sufficient, and it is recommended that this dose be taken whole with some liquid shortly before or during breakfast or - if you skip breakfast - shortly before or during your first main meal.

Your GP will determine the dose and frequency of dosage depending on your blood sugar levels, and these instructions will be printed on the dispensing label attached to your medication.

If you forget to take a dose, start your medication regimen again with your next meal. Do not take increase your dose to make up for a missed one.

Who is Amaryl suitable for?

Amaryl is indicated for treatment of adults with type 2 diabetes who are unable to achieve glycemic (blood glucose) control through diet and exercise alone.

Amaryl can be taken on its own (monotherapy) or in combination with metformin (sitagliptin) or insulin when these have not proved effective enough on their own.

Side effects

Common adverse effects of Amaryl include:

  • Headache
  • Dizziness
  • Nausea
  • Skin rash and allergic reactions Low blood sugar (hypoglycaemia) or symptoms of hypoglycaemia

Very rare side effects include:

  • Diarrhoea
  • Hypersensitivity reactions including breathing difficulties, lowered blood pressure or shock
  • Jaundice
  • Liver problems
  • Metabolic problems
  • Stomach pain and discomfort
  • Vomiting

Who is it not suitable for?

As with any drug, Amaryl is not suitable for everyone - some people should never use it while others should only use it with special care. Glimepiride should not be prescribed to people who:

  • are allergic or sensitive to or have had a reaction to any of the ingredients in the medicine
  • are allergic or sensitive to or have had a bad reaction to sulphonylureas or sulphonylurea-like substances in the past
  • have type 1 diabetes
  • have ketoacidosis
  • have kidney, liver or thyroid problems
  • are pregnant or breastfeeding
  • are on dialysis
  • have adrenal or pituitary gland problems
  • have glucose-6-phosphate dehydrogenase deficiency

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