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Glimepiride 4 Mg Twice A Day

glimepiride 4 mg twice a day


Glimepiride is a long-acting oral anti-diabetic which lower the blood sugar level. It is used only in patients diagnosed with Type II Diabetes. It may be used along with Insulin or other medicines in order to achieve better control over the blood sugar levels. This medicine, when taken along with a controlled diet and regular exercise routine, may give better results.

How to take Glimepiride Tablets

Always take this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure

Taking this medicine

Take this medicine by mouth just before or with the first main meal of the day (usually breakfast).If you do not have breakfast you should take the product on schedule as prescribed by your doctor. It is important not to leave out any meal when you are on Glimepiride Tablets Swallow the tablets whole with at least half glass of water. Do not crush or chew the tablets.

How much to take

The dose of Glimepiride Tablets depends on your needs, condition and results of blood and urine sugar tests and is determined by your doctor. Do not take more tablets than your doctor has prescribed.

  • The usual starting dose is one Glimepiride 1 mg tablet once a day.
  • If necessary, your doctor may increase the dose after each 1 - 2 weeks of treatment.
  • The maximum recommended dose is 6 mg Glimepiride tablet per day.

A combination therapy of glimepiride plus metformin or of glimepiride plus insulin may be started . In such a case your doctor will determine the proper doses of glimepiride, metformin or insulin individually for you  Your dose of Glimepiride tablets may need to be adjusted if you change weight, change your lifestyle, or if you are under a lot of stress.

Side effects

Major & minor side effects for Glimepiride

  • Hypoglycemia
  • Dizziness
  • Headache
  • Nausea
  • Asthenia
  • Flu like symptoms
  • Allergic skin reaction
  • Elevate
  • Jaundice
  • Weight gain

Mechanism of Action of Glimepiride 4mg:

Glimepiride Stimulates The Insulin Release From Functioning Pancreatic Β-Cells And Inhibits Gluconeogenesis At Hepatic Cells. It Also Increases Insulin Sensitivity At Peripheral Target Sites. Onset: Peak Effect: 2-3 Hr. Duration: 24 Hr. Absorption: Completely Absorbed From The GI Tract After Oral Admin. Distribution: Highly Protein Bound. Metabolism: Metabolised Hepatically To 2 Main Metabolites. Excretion: 60% Excreted In Urine And 40% In Faeces (As Metabolites); About 9 Hr (Elimination Half-Life).

Special Precautions for Glimepiride 4mg:

Increased Risk Of CV Mortality. Elderly; Hepatic And Renal Impairment. Syndrome Of Inappropriate Secretion Of Antidiuretic Hormone (SIADH) In Patients With CHF Or Hepatic Cirrhosis. Monitor Blood-Glucose Concentration. Pregnancy, Lactation.

Pregnancy - This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding - This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Stress - Use of this medicine should be discontinued in patients exposed to stressful conditions such as a fever, trauma, surgeries, or accidents since it may not be effective in controlling blood sugar levels in these conditions. Replacement with a suitable alternative should be considered under your doctor's supervision.

Liver/Kidney disease - Glimepiride should be administered with caution in patients with a disorder of kidney and/or liver. Suitable dosage adjustments and monitoring of blood sugar levels are necessary in such cases.

Allergy - This medicine is not recommended for use in patients with known history of allergy to Glimepiride or other drugs belonging to the Sulphonamide class of antidiabetic medicines.

Fluid Retention - Glimepiride can cause retention of fluid in some cases that may lead to severe and harmful effects on the body.

Heart Disease - Glimepiride can cause heart-related complications especially if you have an active disease of the heart.

Weight gain - This medicine may cause a mild to moderate weight gain in some patients.

Hemolytic Anemia - Glimepiride can cause Hemolytic Anemia if you have a rare genetic disorder called G6PD Deficiency.

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