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Glimepiride 2 Mg

glimepiride 2 mg


Glimepride 2 MG Tablet is a long-acting oral anti-diabetic which lower the blood sugar level. It is used only in patients diagnosed with Type II Diabetes. It may be used along with Insulin or other medicines in order to achieve better control over the blood sugar levels. This medicine, when taken along with a controlled diet and regular exercise routine, may give better results.


  • Primary Hypercholesterolemia (high levels of cholesterol in the blood) Glimepiride is used in the lowering of abnormally high levels of lipids in the blood.
  • Mixed Dyslipidemia Glimepiride is used to reduce high levels of LDL cholesterol and triglycerides in the blood (main constituents of body fat in humans and other animals, as well as vegetable fat). It also increases the levels of high density cholesterol.
  • Hypertriglyceridemia Glimepiride is used in the lowering of triglycerides in the blood.
  • Homozygous Familial Hypercholesterolemia Glimepiride is also used in the management of blood cholesterol and lipid levels in cases where the condition is inherited.

Mechanism Of Action

The primary mechanism of action of glimepiride in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells. In addition, extrapancreatic effects may also play a role in the activity of sulfonylureas such as glimepiride. This is supported by both preclinical and clinical studies demonstrating that glimepiride administration can lead to increased sensitivity of peripheral tissues to insulin.

Glimepiride is effective as initial drug therapy. In patients where monotherapy with glimepiride or metformin has not produced adequate glycemic control, the combination of glimepiride and metformin may have a synergistic effect, since both agents act to improve glucose tolerance by different primary mechanisms of action. This complementary effect has been observed with metformin and other sulfonylureas, in multiple studies.

Side effects

Major & minor side effects for Glimepride 2 MG Tablet

  • Hypoglycemia
  • Dizziness
  • Headache
  • Nausea
  • Asthenia
  • Flu like symptoms
  • Allergic skin reaction
  • Elevated liver enzymes
  • Anemia
  • Jaundice
  • Weight gain

General Instructions

Take Glimepride 2 MG Tablet as directed by your doctor. Follow the instructions mentioned on the label. The medicine should be taken orally with breakfast or the first meal of the day. Adequate amount of water should be consumed while taking this medication.

Pregnancy - This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding - This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Hypoglycemia - Glimepride 2 MG Tablet can cause moderate to severe lowering of blood glucose levels. The risks are even greater in elderly, malnourished, people with kidney and pituitary gland disorders. You should report any such incidence to the doctor. Carry a reliable source of glucose like sugar candy to counteract the effect of low blood sugar levels.

Stress - Use of this medicine should be discontinued in patients exposed to stressful conditions such as a fever, trauma, surgeries, or accidents since it may not be effective in controlling blood sugar levels in these conditions. Replacement with a suitable alternative should be considered under your doctor's supervision.

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