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Gliclazide

Gliclazide

About gliclazide

Gliclazide is a medicine used to treat type 2 diabetes. Type 2 diabetes is an illness where the body doesn't make enough insulin, or the insulin that is made doesn't work properly. This causes high blood sugar levels. Gliclazide lowers your blood sugar by increasing the amount of insulin your body produces. Gliclazide is available on prescription. It comes as tablets.

Interactions

Hyperglycemic action may be caused by danazol, chlorpromazine, glucocorticoids, progestogens, or β-2 agonists. Its hypoglycemic action may be potentiated by phenylbutazone, alcohol, fluconazole, β-blockers, and possibly ACE inhibitors. It has been found that rifampin increases gliclazide metabolism in humans in vivo.

Mechanism of action

Gliclazide binds to the β cell sulfonyl urea receptor (SUR1). This binding subsequently blocks the ATP sensitive potassium channels. The binding results in closure of the channels and leads to a resulting decrease in potassium efflux leads to depolarization of the β cells. This opens voltage-dependent calcium channels in the β cell resulting in calmodulin activation, which in turn leads to exocytosis of insulin containing secretorty granules.

How should I use this medication?

The recommended dose of gliclazide ranges from 80 mg to 320 mg daily. Doses of 160 mg and above should be taken in two equally divided doses. Gliclazide should be taken with meals if possible. The daily dose should not exceed 320 mg.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here,do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice. Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Precautions

Tell your doctor if you have: liver problems, kidney problems, any allergies. This medication may make you more sensitive to the sun's effects. Avoid prolonged sun exposure. Wear protective clothing and use an effective sunscreen when outdoors. Notify your doctor if you become ill, are injured or acquire a severe infection. This medication is not recommended for use during pregnancy and should be used only if clearly needed while breast-feeding. Discuss the risks and benefits with your doctor.

General Instructions

Take Gliclazide as directed by your doctor. Follow the instructions mentioned on the label. The medicine should be taken orally with breakfast or the first meal of the day. An adequate amount of water should be consumed while taking this medicine.

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