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Glibenclamide Metformin

Glibenclamide Metformin


Combination of glibenclamide (glyburide in the U.S.) and metformin hydrochloride simultaneously addresses two different but complimentary mechanisms to improve glycemic control in type 2 diabetes.

How it works

Glyburide belongs to a class of drugs called sulfonylureas. Metformin belongs to a class of drugs called biguanides. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Glyburide and metformin work together to improve your blood sugar levels. Glyburide works by helping your body release more insulin. Metformin works by lowering the amount of sugar in your body

How to take glyburide-metformin

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

side effects

The more common side effects that can occur with glyburide/metformin include:

  • diarrhea
  • nausea
  • upset stomach
  • dizziness
  • headache
  • metallic taste in your mouth
  • gas


Surgery or medical procedures warning: If you’re going to have surgery, magnetic resonance imaging (MRI), computerized tomography (CT) scan, or any other procedure, your doctor may temporarily stop your treatment with glyburide/metformin. Having procedures done that use radiocontrast dyes while taking this drug can cause kidney failure or lactic acidosis.

Sun sensitivity warning Glyburide/metformin can make your skin more sensitive to the sun. This means you’re more likely to get sunburned. While you’re taking this drug, use sunscreen and wear protective clothing whenever you’re in the sun. Don’t use sun lamps or tanning beds or booths.

Low blood sugar (hypoglycemia) warning: Glyburide/metformin can cause severe low blood sugar (hypoglycemia). This can cause seizures or fainting. It’s important to know how to spot and treat low blood sugar reactions as directed by your doctor. Symptoms may include:

  • shakiness
  • nervousness or anxiety
  • sweating, chills, and clamminess
  • irritability or impatience
  • confusion
  • rapid or fast heart rate
  • lightheadedness or dizziness
  • intense hunger
  • nausea
  • sleepiness
  • blurred or impaired vision
  • tingling or numbness in your lips or tongue
  • headaches
  • weakness or fatigue

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