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Gentamycin Sulph

Gentamycin Sulph

Description

Gentamicin sulfate is a water-soluble antibiotic originally purified from the fungus Micromonospora purpurea. Gentamicin acts by binding to the 30S subunit of the bacterial ribosome leading to inhibition of protein synthesis and death in susceptible bacteria. Gibco Gentamicin is effective against a wide variety of gram-positive and gram-negative bacteria, and is used to prevent the contamination of cell cultures by bacteria. The recommended working concentration ranges from 0.5 to 50 µg /mL.

Uses

Active against a wide range of bacterial infections, mostly Gram-negative bacteria including Pseudomonas, Proteus, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Serratia, and the Gram-positive Staphylococcus.[9] Gentamicin is used in the treatment of respiratory tract infections, urinary tract infections, blood, bone and soft tissues infections of these susceptible bacteria.[10]

There is insufficient evidence to support gentamicin as the first line treatment of Neisseria gonorrhea infection.[11] Gentamicin is not used for Neisseria meningitidis or Legionella pneumophila bacterial infections (because of the risk of the person going into shock from lipid A endotoxin found in certain Gram-negative organisms). Gentamicin is also useful against Yersinia pestis, its relatives, and Francisella tularensis (the organism responsible for Tularemia seen often in hunters and/or trappers).[12]

Some Enterobacteriaceae, Pseudomonas spp., Enterococci, Staphylococcus aureus and other Staphylococci are resistant to gentamicin sulfate, to varying degrees.

What are the side-effects of Gentamicin Sulph Injection?

The most commonly reported side-effects of Gentamicin Sulph Injection are nephrotoxicity, dizziness, vertigo, tinnitus, roaring in the ears, and hearing loss.

The following is a list of possible side effects that may occur from the use of Gentamicin Sulph Injection. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.

  • Nephrotoxicity
  • Dizziness
  • Vertigo
  • Tinnitus
  • Roaring in the ears
  • Hearing loss
  • Numbness
  • Skin tingling
  • Muscle twitching
  • Convulsions
  • Myasthenia gravis-like syndrome
  • Gentamicin Sulph Injection may also cause side-effects not listed here.

If you notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority.

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