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Galantamine Hydrobromide

galantamine hydrobromide


Galantamine Hydrobromide is the hydrobromide salt form of galantamine, a tertiary alkaloid obtained synthetically or naturally from the bulbs and flowers of Narcissus and several other genera of the Amaryllidaceae family with anticholinesterase and neurocognitive-enhancing activities. Galantamine competitively and reversibly inhibits acetylcholinesterase, thereby increasing the concentration and enhancing the action of acetylcholine (Ach).

In addition, galantamine is a ligand for nicotinic acetylcholine receptors, which may increase the presynaptic release of Ach and activate postsynaptic receptors. This agent may improve neurocognitive function in mild and moderate Alzheimer' s disease and may reduce abstinence-induced cognitive symptoms that promote smoking relapse.

Who might benefit?

Reminyl was designed for people with Alzheimer's disease, and not for people with other kinds of dementia. It is licensed for people who are in the mild to moderately severe stages of Alzheimer’s disease. There is some evidence that it might benefit people with mixed dementia (Alzheimer's disease and vascular dementia).

It is important to realise that Reminyl (or any of the other cholinesterase inhibitors) will not help everyone who tries it. Even in those who do benefit, there can be a lot of variation. For some people, the drug may delay or slow the worsening of some symptoms for anything up to six months or a year; others will see the benefit for much longer.

How does galantamine hydrobromide work?

Acetylcholine is a neurotransmitter, a brain chemical which carries messages between brain cells. When someone has Alzheimer's disease, it seems that, among other changes, his or her brain produces less acetylcholine. Normally there is a repeated cycle in the brain in which acetylcholine is made, transmits messages and is then broken down by a special enzyme (acetylcholinesterase). Reminyl aims to prevent the last part of this cycle so that the acetylcholine is not broken down. There is then more acetylcholine available in the brain to carry messages between the brain cells. Reminyl also affects another part of the cycle, which results in an improvement in the effectiveness of acetylcholine in carrying messages between brain cells.

How is galantamine hydrobromide taken?

Reminyl comes in three forms: as 8mg and 12 mg tablets; as Reminyl XL in 8mg, 16mg and 24mg prolonged release capsules; and as an oral solution. You should read the patient information leaflet that comes with each form of the drug and take the drug as directed by the doctor who prescribed it. Treatment will normally start with a low dose and the doctor will gradually increase the dose, depending on how you respond to the treatment. Your doctor will need to see you regularly to check that this medicine is working for you and to discuss how you are feeling. He or she will also check your weight regularly while you are taking Reminyl.

side effects galantamine hydrobromide

Although you should report any side effects to your doctor, there are some things you can do yourself to help you cope with some of the more common ones:  if you feel or are sick or have indigestion or stomach pain, try eating little and often and sticking to simple foods. If you have diarrhoea, drink plenty of water to make up for lost fluids  If you develop headaches, ask your pharmacist to recommend a suitable painkiller. If headache persists though, report it to your doctor  If you feel drowsy, dizzy or tired, you should not do anything that would normally require you to be fully alert, like driving or operating machinery  If you find yourself sweating more than usual, take care not to become overheated during exercise or hot weather. You may also have to drink more fluids to compensate.

If you have taken too much Reminyl, contact a doctor or hospital straight away for advice. Take any remaining tablets and the packaging with you. NHS 24 (telephone 08454 24 24 24) may be able to give you advice over the phone when your GP practice or health centre is closed.

Warning galantamine hydrobromide

is one of the drugs currently recommended as a treatment option for managing mild to moderate Alzheimer’s disease. Because of this, people with dementia who their doctors believe may benefit from it should have no difficulty obtaining Reminyl.

If you or the person you care for are told they cannot have it, there are likely to be good medical reasons which the doctor should explain to you. No-one should attempt to obtain supplies of Reminyl (or any generic equivalent) by ordering it over the Internet.

There are many overseas online pharmacies or websites offering drugs without prescription. Overseas suppliers are not subject to the same controls as UK companies and many have websites which advertise the supply of drugs which are only available on prescription in Britain.

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