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Fosfomycin

Fosfomycin

Description

Fosfomycin is an antibiotic that fights infection caused by bacteria. Fosfomycin is used to treat bladder infections. Fosfomycin may also be used for purposes not listed in this medication guide.

What Is Fosfomycin?

Fosfomycin is an antibiotic that fights infection caused by bacteria. Fosfomycin is used to treat bladder infections. Fosfomycin may also be used for purposes not listed in this medication guide.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.You should not use fosfomycin if you are allergic to it. FDA pregnancy category B. Fosfomycin is not expected to harm an unborn baby. Tell your doctor if you are pregnant.

Uses

Fosfomycin is indicated in the treatment of urinary tract infections (UTIs), where it is usually administered as a single oral megadose. Its use in combination with tobramycin to treat lung infections in patients with cystic fibrosis was also explored.

The drug is well tolerated and has a low incidence of harmful side effects. However, development of bacterial resistance under therapy is a frequent occurrence and makes fosfomycin unsuitable for sustained therapy of severe infections. It is not recommended for children and those over 75 years old. Additional uses have been proposed. The global problem of advancing antimicrobial resistance has led to a renewed interest in its use more recently.

Fosfomycin Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • diarrhea that is watery or bloody; or
  • new or worsening bladder symptoms (burning, painful urination).

Common side effects may include:

  • nausea, upset stomach, mild diarrhea;
  • headache, dizziness;
  • weakness;
  • sore throat, runny nose;
  • back pain; or
  • vaginal itching or discharge.

Fosfomycin Dosage

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Fosfomycin is usually given in only one dose. Do not take more than a single dose unless your doctor tells you to.You may take fosfomycin with or without food. Fosfomycin is a powder medicine that must be mixed with water before using it. Do not take the dry powder without adding water.

Mechanism of action

Fosfomycin is bactericidal and inhibits bacterial cell wall biogenesis by inactivating the enzyme UDP-N-acetylglucosamine-3-enolpyruvyltransferase, also known as MurA.This enzyme catalyzes the committed step in peptidoglycan biosynthesis, namely the ligation of phosphoenolpyruvate (PEP) to the 3'-hydroxyl group of UDP-N-acetylglucosamine. This pyruvate moiety provides the linker that bridges the glycan and peptide portion of peptidoglycan. Fosfomycin is a PEP analog that inhibits MurA by alkylating an active site cysteine residue (Cys 115 in the Escherichia coli enzyme)

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug include: metoclopramide, probenecid.

Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics (such as rifampin, rifabutin) can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control, ask your doctor or pharmacist for more details.

Precautions

Before taking fosfomycin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease.

If you develop symptoms of a kidney infection (such as pain in your side or lower back area, fever, chills), contact your doctor right away. Your doctor may change your treatment.

This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.

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