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Etidronate Sodium

Etidronate Sodium

Description

Injectable and oral first-generation bisphosphonate with a lower potency and selectivity vs. newer second- and third-generation bisphosphonates

For Paget's disease the drug has largely been replaced by newer bisphosphonates that are easier to use and have greater antiresorptive potency; also indicated for heterotopic ossification but treatment is costly

Not recommended by guidelines for osteoporosis treatment or prevention as lacks efficacy data proving fracture reduction

Uses

Etidronate is used to treat a certain type of bone disease called Paget's disease. This disease weakens and deforms bones. Etidronate works by slowing bone loss, helping to keep your bones strong and less likely to break. It also helps reduce bone pain from this disease. This medication belongs to a class of drugs called bisphosphonates.

Etidronate is also used to prevent or treat bone problems that may occur after hip replacement surgery or spinal cord injury.

How to use Etidronate Disodium

Follow these instructions very closely to make sure you absorb as much of the drug as possible and reduce the risk of injury to your esophagus. Consult your doctor or pharmacist if you have any questions.

Take this medication by mouth without food, usually once a day or as directed by your doctor. Take it on an empty stomach at least 2 hours before or 2 hours after a meal.

Take etidronate with a full glass of plain water (6 to 8 ounces, 180 to 240 milliliters). Do not take it with any other beverage. After taking etidronate, stay fully upright (sitting, standing, or walking) and do not lie down for at least 30 minutes.

Etidronate Disodium Side-effects

The following is a list of possible side-effects that may occur in medicines that contain Etidronate Disodium. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.

  • Gastrointestinal symptoms
  • Abdominal pain
  • Constipation
  • Diarrhoea
  • Nausea
  • Recurrent bone pain at pagetic sites or the onset of pain at previously asymptomatic sites
  • Metallic or altered or loss of taste during or shortly after the treatment
  • Headache
  • Tingling or prickling
  • Reduction in the number of white cells in the blood

Interactions

Your doctor or pharmacist may already be aware of any possibledrug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

This medication may affect the results of certain lab tests (bone imaging tests). Make sure laboratory personnel and all your doctors know you use this drug.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Precautions

Before taking etidronate, tell your doctor or pharmacist if you are allergic to it; or to other bisphosphonates (such as alendronate); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: a certain bone disorder that causes soft/painful bones (osteomalacia).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, inability to sit upright or stand for at least 30 minutes, difficult/painful swallowing, esophagus problems (such as esophageal stricture, achalasia), stomach/intestinal problems (such as heartburn, ulcers, colitis), low level of calcium in the blood.

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