My Cart

0 Item(s): $0.00

You have no items in your shopping cart.

Estradiol Gel

Estradiol Gel

How does this medication work? What will it do for me?

Estradiol gel belongs to the class of medications known as estrogen replacement therapy. It is used to manage menopausal symptoms such as hot flashes, irritation of the vagina, and sleep disturbances. When estradiol gel is applied to your skin, it releases estradiol into your blood through your skin.

Estradiol is a type of estrogen, a female hormone that is produced by the ovaries. At menopause, the amount of estrogen made by the ovaries declines and symptoms such as hot flushes (sudden, extreme feeling of warmth) and vaginal dryness can occur. Most women reach menopause naturally around the age of 50, but some women may undergo menopause sooner, due to many causes, including surgery.


This medication is a female hormone (estrogen). It is absorbed through the skin and enters into the bloodstream. It is used by women to help reduce a certain symptom of menopause (hot flashes). Symptoms of menopause are caused by the body making less estrogen. If you are using estrogens to treat only vaginal symptoms of menopause (such as vaginal dryness/burning/itching), products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected.

How to use Estradiol Gel In Packet

Read the Patient Information Leaflet if available from your pharmacist before you start using this medication and each time you get a refill. Learn how to apply the gel correctly. If you have any questions, ask your doctor or pharmacist.

Apply the medication to clean, dry skin on the upper thigh area as directed by your doctor, usually once daily. Switch between the right and left thigh with each application. Avoid applying this medication to broken, irritated skin. Do not apply this medication to the breast, face, or in or around the vagina. Do not let others apply this medication to your body.

The dosage is based on your medical condition and response to treatment. Do not increase your dose or use this medication more often than prescribed.

Side effects

  • darkening of the skin
  • decreased interest in sexual activity
  • fatigue
  • fluid retention
  • hair loss
  • irritability
  • migraine headaches
  • nausea
  • nervousness
  • stomach cramps and bloating

Who should not take this medication?

Do not use this medication if you:

  • Are allergic to estradiol gel or any ingredients of the medication
  • Are or may be pregnant or breast-feeding
  • Experience migraines that are accompanied by a visual aura or disturbance
  • Have active phlebitis (inflamed varicose veins)
  • Have heart disease or have had a stroke
  • Have had breast or endometrial cancer, except in special circumstances


Do not smoke or use tobacco. Estrogens combined with smoking further increases your risk of stroke, blood clots, high blood pressure, and heart attack, especially in women older than 35.

Tell your doctor if you just had or will be having surgery, or if you will be confined to a chair or bed for a long time (such as a long plane flight). These conditions increase your risk of getting blood clots, especially if you are using an estrogen product. You may need to stop this medication for a time or take special precautions.

This drug may cause blotchy, dark areas on your face and skin (melasma). Sunlight may worsen this effect. Limit your time in the sun. Avoid tanning booths and sunlamps. Wear protective clothing when outdoors. Ask your doctor or pharmacist about using sunscreen with this medication. Sunscreen may affect the absorption of this medication if applied on the area of the skin where the medication was applied.