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Donepezil Drug

donepezil drug


Donepezil is used to treat dementia (memory loss and mental changes) associated with mild, moderate, or severe Alzheimer's disease. Donepezil will not cure Alzheimer's disease, and it will not stop the disease from getting worse. However, it can improve thinking ability in some patients.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet, Disintegrating
  • Tablet


Donepezil is used to treat confusion (dementia) related to Alzheimer's disease. It does not cure Alzheimer's disease, but it may improve memory, awareness, and the ability to function. This medication is an enzyme blocker that works by restoring the balance of natural substances (neurotransmitters) in the brain.

Drug interactions

Drug-drug. Anticholinergics: May interfere with anticholinergic activity. Monitor patient.

Bethanechol, succinylcholine: May produce additive effects. Monitor patient closely.

Carbamazepine, dexamethasone, phenobarbital, phenytoin, rifampin: May speed donepezil elimination. Monitor patient.

Cholinomimetics, cholinesterase inhibitors: May produce synergistic effect. Monitor patient closely.

NSAIDs: May increase gastric acid secretion because of donepezil’s cholinergic activity. Monitor patient for active or occult GI bleeding.

Drug-herb. Jaborandi, pill-bearing spurge: May cause additive effect; may increase risk of toxicity. Tell patient to use together cautiously.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions.

Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.

 Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include:

aspirin/non-steroidal anti-inflammatory drugs (NSAIDs, such as ibuprofen, naproxen).Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (NSAIDs such as aspirin, ibuprofen, or naproxen) that if taken together with donepezil may increase your risk for stomach/intestinal bleeding. Low-dose aspirin, as prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention (usually at dosages of 81-325 milligrams per day), should be continued. Consult your doctor or pharmacist for more details.

Drugs with anti-cholinergic properties that counteract donepezil and should be avoided include:

  • Bentropine (Cogentin)
  • Atropine (Atropine Sulfate)
  • Trihexyphenidyl (Artane)

The following medications, which increase enzymes in the liver, may reduce the effect of donepezil:

  • Phenobarbital (Luminal)
  • Phenytoin (Dilantin)
  • Rifampin (Rifadin)
  • Carbamazepine (Tegretol)
  • Dexamethasone (Decadron)

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