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Does Nolvadex Boost Testosterone

does nolvadex boost testosterone

Testosterone and Nolvadex (Tamoxifen)

Nolvadex (tamoxifen) is a SERM (Selective Estrogen Receptor Modulator) from the same class of medications that Clomid is in.  Clomid is widely used by men to boost testosterone (and improve fertiliy) and, as of this writing, about 8% of the men who took a Peak Testosterone poll on T-boosting therapies were on Clomid. That works out to about one out of every thirteen men. SERMs are very convenient, generally inexpensive and (in most men) help keep the testicles fully functional and active. They work by inhibiting negative feedback at the hypothalamus and so, for men with a working hypothalamus and pituitary, are a pretty well-accepted way to bring the testes back online.

Nolvadex uniquely has a couple of other nice advantages: it can help some men with gynocomastia and possibly elevated prolactin.  (See my page on Tamoxifen and Prolactin for more information.)  It does the former due to the fact it has some anti-estrogen properties.

What will it do to male testosterone levels? Unfortunately, that has never been studied thoroughly. However, we do have clues from a 2009 study on men with mild infertility. When these men were given Nolvadex (tamoxifen), their average testosterone levels went from 496 ng/dl to 835 and 763 ng/dl after 2 and 3 months, respectively.  Those are respectable 68% and 54% increases in testosterone.  We had one poster on The Peak Testosterone Forum that experienced an even bigger jump on Nolvadex and more than doubled his testosterone from a baseline of about 300 ng/dl up to 700 ng/dl. [4]

Nolvadex Safety Information/Warnings

Hypercalcemia is one of the rare but serious side effects of Nolvadex. If you experience any symptoms of severe hypercalcemia (arrhythmia, loss of consciousness, kidney stones), the application of antineoplastic drug Nolvadex should be immediately stopped.

Nolvadex Side Effects

Usually Nolvadex may cause mild to moderate adverse reactions, seldom resulting in withdrawal of therapy with the hormonal antineoplastic agent. The frequency and intensity of adverse reactions of Nolvadex can be controled by reducing the drug dosage. The most common adverse reactions caused by Nolvadex are as follows: vomiting, nausea or hot flushes. Sometimes Nolvadex tablets may cause hypercalcaemia, dizziness, menstrual irregularities, lightheadedness, alopecia, vaginal bleeding and peripheral oedema.

What Does Tamoxifen Do?

Tamoxifen is classed as a specific estrogen receptor modulator or SERM. It acts as an estrogen antagonist in the brain and the breast area meaning it prevents estrogen from exerting its normal effect in those areas. With respect to its action in the brain it inhibits the conversion of testosterone to estrogen which during a cycle can mean that estrogen levels remain low. Although low estrogen is often considered advantageous by bodybuilders it should be noted that estrogen helps both with the accrual of muscle mass and also helps to boost libido on cycle. In fact, when bodybuilders use testosterone enhancing compounds and run tamoxifen alongside it, they often lose out on some of the muscle gains and enhanced libido that normally accompanies testosterone elevation.

Other Health Effects

Carcinogenic action - Tamoxifen has been shown in several studies 4,5,6) to increase the risk of cancer and is listed as a known carcinogen by the American Cancer Society. A 2006 study in The Lancet showed it increased mortality rate in women using tamoxifen. Studies in rats (7) add further weight to the argument supporting tamoxifen's carcinogenic potential with up to 80% of animals developing malignant tumours.

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