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Does Glipizide Cause Weight Gain

does glipizide cause weight gain

Gaining Weight? Your Medication May Be to Blame

Gaining weight or struggling to lose weight is frustrating. You might feel like you’re doing all the “right” things: eating healthful foods, exercising, keeping food records, getting enough sleep, and so on. Yet despite all of your efforts, the scale doesn’t seem to budge. What gives? There are so many factors that affect our weight, and food isn’t always the culprit. One of the factors that may, in part, be contributing to some weight gain is medication.

The link between medication and weight

If you have diabetes, chances are, you’re taking some form of medication. It might be medication to help you manage your blood sugars. You might also be taking medication to keep your blood pressure or your cholesterol numbers in check. And you might even be taking a medication to help you better cope with the stress of having a chronic condition. While all of these drugs are effective (or else why would you be taking them?), the reality is that, like all medications, some of them have side effects that can make it difficult to reach your weight goal or can even lead to weight gain. To be more specific, these meds might:

  • Jump-start your appetite, causing you to eat more than you usually might
  • Slow your metabolism so that you burn fewer calories
  • Affect how glucose is stored in the body, leading to increased fat storage
  • Cause fluid retention
  • Make you feel tired or sluggish, which can prevent you from being as active as you might like


Glipizide should not be taken if certain medical conditions develop, such as kidney or liver disease, dehydration, infections, heart problems or poor circulation. Read the drug's warning labels for possible side effects besides weight gain.

What Are the Downsides of Taking Glipizide?

In some patients taking Glipizide, the medication has lost its effectiveness over time.

When compared to some other diabetes medications, Glipizide does have a higher risk for causing low blood sugar levels.

Glipizide may also cause slight weight gain, averaging 2-3 pounds per week.

It has been stated that for Glipizide to be effective, it needs to be taken about 30 minutes before mealtime.

One study has shown that, when compared to insulin treatment, Glipizide may increase the risk of heart-related conditions.

Glipizide is used for Type 2 diabetes treatment and is not used in the treatment of Type 1 diabetes.

Glipizide may interact with other medications you may be taking including anti-nausea medications, anti-psychotic medications, beta blockers, calcium channel blockers, corticosteroids,  decongestants, diuretics, estrogens, eye infection medications, gout medications, monoamine oxidase inhibitors, niacin, nonsteroidal anti-inflammatory drugs, oral contraceptives, thyroid medications and tuberculosis-treatment medications.

Are There Other Comparable Treatments to Glipizide?

There are times when you or your doctor may recommend a Glipizide alternative, if the side effects bother you too much or the drug just isn’t working effectively.

Lifestyle changes may be one option, which includes diet and exercise adjustments. Another option is to prescribe a different diabetes medication.

This includes medications like Biguanides, which help your body use its natural insulin more effectively, including Metformin; Meglitinides, which are designed to help your pancreas produce more insulin, including Prandin; Thiazolidinediones, which work much like Biguanides, including Avandia and Alpha Glucosidase Inhibitors, which are designed to break down carbohydrates and sugar in the body’s digestive tract, including Precose.

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