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Disulfiram Like Action

disulfiram like action

Disulfiram-like reactions

There are a number of medications that produce the disulfiram-like reaction when ingested with alcohol. The disulfiram reaction is a very uncomfortable reaction characterized by severe flushing, and may be accompanied by tachycardia and hypotension. Although we always think of metronidazole, there have been well described cases of bactrim causing this reaction. Tinidazole, a new antiprotozoal used in the treatment of trichomonas, causes this as well. Patients should be advised to avoid alcohol for 24 hours after metronidazole, and 72 hours after bactrim and tinidazole.

Disulfiram is an oral drug used for treating alcoholism. Alcohol is converted in the body into acetaldehyde by an enzyme called alcohol dehydrogenase. Another enzyme called acetaldehyde dehydrogenase then converts acetaldehyde into acetic acid. Disulfiram prevents acetaldehyde dehydrogenase from converting acetaldehyde into acetic acid, leading to a buildup of acetaldehyde levels in the blood.

how should i take disulfiram (antabuse)?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended. Wear a medical alert tag or carry an ID card stating that you take disulfiram. Any medical care provider who treats you should know that you are using disulfiram.

When disulfiram is used as part of a treatment program for alcohol addiction or detoxification, your doctor may recommend that this medicine be given to you by a family member or other caregiver. This is to make sure you are using the medicine as it was prescribed as part of your treatment.

Do I need a prescription for this drug?

Yes, you need a prescription from your doctor or other health care professional for this medication.

conclusions:

This study shows that metronidazole does not have an effect on blood acetaldehyde concentrations when ingested with ethanol and does not have any objective or subjective disulfiram-like properties. However, it is possible that disulfiram-like reaction can occur in some subgroups and by other mechanisms than the inhibition of hepatic ALDH.

what should i avoid while taking disulfiram (antabuse)?

Do not drink alcohol while taking disulfiram. Avoid situations that might tempt you to drink.Be aware that many common products contain small amounts of alcohol, enough to cause a disulfiram reaction. Such products include aftershave, cologne, perfume, antiperspirant, mouthwash, antiseptic astringent skin products, hair dyes, and others. Check the label to see if any food or medicine product contains alcohol. Ask your pharmacist if you have questions.

Avoid coming into contact with non-consumable products that may contain alcohol: paint thinners, solvents, stains, lacquers and others. Avoid coming into contact with or breathing the fumes of pesticides or chemicals used in manufacturing or certain other industries (waxes, dyes, resins, and gums).

Other drugs may interact with disulfiram, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

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