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What Is Disopyramide?

Disopyramide affects the way that your heart beats.

Disopyramide is used to treat life-threatening irregular heartbeat patterns.

Disopyramide may also be used for purposes not listed in this medication guide.

You should not use disopyramide if you have long QT syndrome, or a serious heart condition such as "AV block" (unless you have a pacemaker).


This medication is used to treat certain types of serious (possibly fatal) irregular heartbeat, such as persistent ventricular tachycardia. It is used to restore normal heart rhythm and maintain a regular, steady heartbeat. Disopyramide is known as an anti-arrhythmic drug. It works by blocking certain electrical signals in the heart that can cause an irregular heartbeat. Treating an irregular heartbeat can decrease the risk for blood clots, and this effect can reduce your risk of heart attack or stroke.

How should this medicine be used?

Disopyramide comes as a capsule to take by mouth. Immediate-acting disopyramide may be taken 3 to 4 times a day. The long-acting product is usually taken twice a day. Do not cut, crush, or chew extended-release capsules; swallow them whole.

Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take disopyramide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Disopyramide helps control your condition but will not cure it. Continue to take disopyramide even if you feel well. Do not stop taking disopyramide without talking to your doctor.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will need to determine your response to disopyramide.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Contraindications and precautions

Contraindicated in patients hypersensitive to drug and in those with cardiogenic shock or second- or third-degree heart block in the absence of an artificial pacemaker, in congenital QT prolongation, and sick sinus syndrome.

  Use very cautiously and, if possible, avoid in patients with heart failure. Use cautiously in patients with underlying conduction abnormalities, urinary tract diseases (especially prostatic hyperplasia), hypotension, hepatic or renal impairment, myasthenia gravis, or acute angle-closure glaucoma.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of disopyramide can be fatal. Overdose symptoms may include trouble breathing, irregular heartbeats, and loss of consciousness.