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Difference Between Famotidine And Ranitidine

difference between famotidine and ranitidine


Pepcid (famotidine) is an H2-blocker used to treat and prevent recurrence of stomach and duodenal ulcers. Pepcid is also useful in managing heartburn, gastroesophageal reflux disease and Zollinger-Ellison syndrome. Pepcid is available as a generic drug.


Zantac (ranitidine hydrochloride) is a H2 (histamine-2) receptor blocker used for treating and preventing ulcers in the duodenum and stomach. Zantac is also used for treating:

  • heartburn,      
  • erosive esophagitis,
  • and Zollinger Ellison syndrome.

Zantac vs Pepcid

Hyperacidity or an oversecretion of gastric acid may occur in some people, and they just have to find ways in order to suppress it. Thank God, certain medications are already available in the market that can help clear up some of the unwanted symptoms that this condition exhibits. Among this line of gastric relieving medications are Zantac and Pepcid which are two of the most popular in the marketFamotidine is the generic name of Pepcid while Ranitidine is the generic name of Zantac. Both drugs are histamine 2 blockers or also known as antihistamines. Histamine 2 blockers work by reducing the amount of gastric acid being produced by the stomach.Pepcid is prescribed by physicians for people having heartburn. Pepcid is commonly indicated for this. Zantac, on the other hand, is prescribed for people who have ulcers, GERD, and, in extreme cases, Zollinger-Ellison syndrome.A patient with heartburn with unrelieved signs and symptoms after taking Pepcid must be able to determine the difference between heartburn and heart attack which have the same symptoms such as chest pain, pain that radiates into the left arm, nausea, and vomiting. If these are already intense and unbearable in nature, one should already go to the nearest hospital as this might be a heart attack already.

Is ranitidine or famotidine better?

Therapeutic trials indicate that famotidine 20 mg b.i.d. or 40 mg at bedtime is as effective as standard doses of cimetidine and ranitidine for healing duodenal ulcers. A dose of 40 mg at bedtime appears to heal benign gastric ulcers. A single nocturnal dose of 20 mg is effective in preventing duodenal ulcer relapse.


Pepcid (famotidine) and Zantac (ranitidine hydrochloride) are H2-blockers used to treat and prevent recurrence of stomach and duodenal ulcers. Pepcid is also useful in managing heartburn, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome.Pepcid and Zantac are available over-the-counter (OTC) and in generic form.


Pepcid (famotidine) dosage depends on the condition being treated.


Zantac is available in tablet, syrup, and injectable formulations.

adults and children 12 years and over:to relieve symptoms, swallow 1 tablet with a glass of water,to prevent symptoms, swallow 1 tablet with a glass of water 30 to 60 minutes before eating food or drinking beverages that cause heartburn,can be used up to twice daily (do not take more than 2 tablets in 24 hours)

How they work

Prilosec is a brand name for the generic drug omeprazole. It works by blocking the pumps in your stomach that produce acid. Zantac is a brand name for a different generic drug, ranitidine. Zantac blocks a chemical in your body called histamine that activates the acid pumps.

Dosage forms Zantac

  • Pill
  • Oral solution
  • Oral syrup
  • Injection

Dosage forms Pepcid

  • Pill
  • Chewable tablet
  • Liquid

Side effects

Like most medications, Prilosec and Zantac can cause side effects. Their more common side effects are similar and can include:

  • headache
  • diarrhea
  • constipation
  • stomach pain
  • gas
  • dizziness
  • drowsiness

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