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Diclofenac Sodium –Misoprostol

Diclofenac Sodium – Misoprostol

What Is Diclofenac-Misoprostol?

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Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing substances in the body that cause pain and inflammation.

Misoprostol reduces stomach acid and replaces protective substances in the stomach that are reduced by nsaids.

Diclofenac and misoprostol is a combination medicine used to treat osteoarthritis and rheumatoid arthritis in people at high risk for developing stomach or intestinal ulcers.

Diclofenac and misoprostol may also be used for purposes not listed in this medication guide.

Do not use if you are pregnant. Misoprostol can cause birth defects, miscarriage, premature labor, or rupture of the uterus.

Diclofenac-Misoprostol Dosage

Follow all directions on your prescription label. Do not take this medicine in larger amounts or for longer than recommended. Use the lowest dose that is effective in treating your condition.

Take diclofenac and misoprostol with food or milk to lessen stomach upset.

Swallow the tablet whole. Do not crush, break, or chew the pill.

Do not share this medicine with anyone else, even if they have the same symptoms you have.

If you use diclofenac and misoprostol long-term, you may need frequent medical tests at your doctor's office.

Store at room temperature away from moisture and heat.

Why it’s used

Diclofenac-misoprostol is used to treat the symptoms of rheumatoid arthritis and osteoarthritis. Your doctor may prescribe this medication if you’re at risk of stomach ulcers from other pain medications.

Diclofenac-Misoprostol Side Effects

Stop using this medicine and call your doctor at once if you have:

  • the first sign of any skin rash, no matter how mild;
  • shortness of breath (even with mild exertion);
  • swelling or rapid weight gain;
  • signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • liver problems--nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • kidney problems--little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath;


For people with stomach bleeding: Don’t take this medication if you have an active bleed in your stomach or intestines. Use it with caution if you have a prior history of stomach ulcers or bleeding.

For people with heart problems: This medication can increase the risk of serious heart problems, such as heart attack and stroke, in people who have heart disease or risk factors.

Use this medication with caution if you have high blood pressure. It can worsen blood pressure, which can raise your risk of heart problems. Monitor your blood pressure closely while taking this medication.

For people with kidney disease: If you have kidney disease, use this medication with caution. If you have advanced kidney disease, don’t take it at all. This medication is removed through your kidneys. Your kidneys may not be able to remove the drug from your body like it should. This can cause a buildup of the drug in your body, which can cause dangerous effects.


Store at controlled room temperature (between 68 and 77 degrees F)

Store in a dry place