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Diclofenac Sodium - Misoprostol

Diclofenac Sodium - Misoprostol

What Is Diclofenac-Misoprostol?

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing substances in the body that cause pain and inflammation.

Misoprostol reduces stomach acid and replaces protective substances in the stomach that are reduced by NSAIDs.

Diclofenac and misoprostol is a combination medicine used to treat osteoarthritis and rheumatoid arthritis in people at high risk for developing stomach or intestinal ulcers.

Why it’s used

Diclofenac-misoprostol is used to treat the symptoms of rheumatoid arthritis and osteoarthritis. Your doctor may prescribe this medication if you’re at risk of stomach ulcers from other pain medications.

How it works

This medication is a combination of diclofenac and misoprostol. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). Misoprostol is a prostaglandin analog.

Diclofenac works to reduce pain, swelling, and fever. However, NSAIDs can cause stomach and intestinal ulcers. Misoprostol works to reduce the risk of stomach ulcers in people who take NSAIDs.

side effects

The more common side effects that can occur with diclofenac-misoprostol include:

  • diarrhea
  • dizziness
  • gas or heartburn
  • headache
  • menstrual cramps and menstrual irregularity
  • stomach cramps and stomach pain
  • nausea or vomiting
  • constipation
  • increase in liver enzymes


This drug has black box warnings. A black box warning is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients about drug effects that may be dangerous.

Pregnancy warning: Don’t take this medication if you’re pregnant or trying to get pregnant. This medication can harm your pregnancy. Talk to your doctor right away if you’re taking this medication and think you have become pregnant.

Heart surgery warning: If you use this drug and are going to have a procedure called coronary artery bypass graft, you’ll need to stop taking this medication before surgery. Talk to your doctor about when you need to stop taking it and how long after the procedure you have to wait before taking it again.

Heart problems warning: This medication can increase the risk of heart problems, such as heart attack and stroke. This risk is greater for people who have heart disease. These conditions can be fatal. The longer you take this medication, the more the risk of heart problems increases.

Gastrointestinal problems warning: This medication can increase the risk of gastrointestinal problems, such as bleeding, ulcers, or holes in your stomach and intestines. These conditions can be fatal. These problems can happen at any time and sometimes without any warning. People older than 65 years are at an increased risk of these problems.