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Desmopressin For Bedwetting

desmopressin for bedwetting

Bedwetting Treatment

Treating bedwetting isn't an exact science. Since it's very common until 6 years of age, we generally don't try to treat it earlier. At any age, decisions regarding treatment should consider to what extent the problem affects the child and the child's social development. Many young children and their parents are better served by reassurance that there's no physical abnormality than by long-term and expensive therapy of uncertain effectiveness.

Treatment may consist of medication, conditioning and behavior modification, or a combination of approaches.


Desmopressin is used to control the amount of urine your kidneys make. Normally, the amount of urine you make is controlled by a certain substance in the body called vasopressin. In people who have "water diabetes" (diabetes insipidus) or certain kinds of head injury or brain surgery, the body does not make enough vasopressin. Desmopressin is a man-made form of vasopressin and is used to replace a low level of vasopressin. This medication helps to control increased thirst and too much urination due to these conditions, and helps prevent dehydration.

Desmopressin is also used to control nighttime bedwetting in children. It reduces how often your child urinates and decreases the number of bedwetting episodes.


DDAVP (desmopressin acetate) mimics the natural hormone that causes the kidneys to conserve body water and concentrate the urine, decreasing urine output during sleep.


  • Significantly improves bedwetting in 25 to 65 percent of children; 12 to 40 percent of kids achieve complete dryness
  • Is generally recommended in children older than 6 years
  • Can be used as needed for overnight trips once the correct dosage has been established

Side effects are minimal, if any. However, the drug is expensive and about 80 percent of children who stop taking it will relapse. The optimal duration of treatment is unknown.

The dosage is one 0.2 mg tablet at bedtime for one week. If your child becomes dry, continue at this dose. If your child remains wet, increase the dose to two 0.2 mg tablets for one week. If your child becomes dry, stay at this dosage. If your child remains wet, increase the dose to three 0.2 mg tablets for one week. If your child becomes dry, continue at this dose. If not, discontinue the medication and call our office.


Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug are: tolvaptan, "water pills"/diuretics (such as furosemide).


Before taking desmopressin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, high blood pressure, heart disease (such as blocked blood vessels in the heart), conditions that may increase your risk of fluid/mineral imbalance (such as cystic fibrosis, heart failure), the urge to drink too much water without being thirsty, a low level of sodium in the blood (hyponatremia), bleeding/clotting problems.

If you have lost too much body water (become dehydrated), your doctor will correct that condition first before starting treatment with desmopressin.

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