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Darunavir

Darunavir

What is darunavir?

Darunavir is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 3 years of age and older. Darunavir is always used in combination with the HIV medicine ritonavir (brand name: Norvir) and other HIV medicines.

Darunavir belongs to a class of HIV drugs called protease inhibitors (PIs). PIs block an HIV enzyme called protease. By blocking protease, PIs prevent HIV from multiplying and can reduce the amount of HIV in the body.

Why is this medication prescribed?

Darunavir is used with ritonavir (Norvir) and other medications to treat human immunodeficiency virus (HIV) infection in adults and children 3 years of age and older. Darunavir is in a class of medications called protease inhibitors. It works by decreasing the amount of HIV in the blood. Although darunavir does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other life-style changes may decrease the risk of transmitting the HIV virus to other people.

Side effect

Major and Minor Darunavir side effect

  • headache
  • diarrhea
  • vomiting
  • stomach pain
  • constipation
  • rash
  • peeling or blistering skin
  • mouth sores
  • red, swollen, itchy, or teary eyes
  • muscle or joint aches
  • fever
  • swelling, tenderness, redness, or other signs of infection
  • nausea
  • extreme tiredness

What should I do if I forget a dose?

If you are taking darunavir once a day and you miss a dose by less than 12 hours, take the missed dose as soon as you remember it and then take the next dose at the scheduled time. However, if you miss a dose by more than 12 hours, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

If you are taking darunavir twice a day and you miss a dose by less than 6 hours, take the missed dose as soon as you remember it and then take the next dose at the scheduled time. However, if you miss a dose by more than 6 hours, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Dosing Considerations

In treatment-experienced patients, treatment history, genotypic and/or phenotypic testing is recommended to assess drug susceptibility of the HIV-1 virus

Obtain appropriate laboratory testing (eg, serum liver biochemistries) before initiating darunavir

Patients with underlying chronic hepatitis, cirrhosis, or those who have pretreatment liver enzyme should be monitored for elevated transaminases, especially during the first several months.

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