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Clomiphene Citrate

Clomiphene Citrate

How does Clomiphene Citrate work?

Clomiphene triggers the brain’s pituitary gland to secrete an increased amount of follicle stimulating hormone (FSH) and LH (luteinizing hormone). This action stimulates the growth of the ovarian follicle and thus initiates ovulation.

During a normal menstrual cycle only one egg is ovulated. The use of clomiphene often causes the ovaries to produce two or three eggs per cycle. Clomiphene is taken orally for 5 days and is active only during the month it is taken.

How to use

Clomiphene must be taken by mouth exactly as directed by your doctor in order to be most effective. It is important to follow your dosing schedule carefully.Your dosage is based on your medical condition and response to therapy. Do not take it more often or for a longer time than prescribed by your doctor. Long-term treatment with this medication is not recommended and should not be more than 6 cycles.You may be directed to record your body temperature, perform ovulation tests, and properly time sexual intercourse for best results. Ask your doctor if you have any questions.

Does clomifene citrate have any side-effects?

Clomifene citrate can cause a wide range of minor side-effects, including:

  • hot flushes
  • headaches
  • abdominal bloating and pain
  • nausea and vomiting
  • mood changes, such as depression
  • breast tenderness

Doses of 100g or more may also cause your cervical mucus to become drier, although it’s unknown whether that would make it harder for you to get pregnant.

Visual disturbances, such as blurred vision, are uncommon but if you experience this you should tell your doctor as soon as possible, as you may need to stop taking the drug.

When is Clomid prescribed?

Clomid is prescribed off-label for male infertility, particularly where low testosterone levels are observed. According to the U.S. Centers for Disease Control and Prevention, both a male and a female factor are identified in 35 percent of couples that struggle to conceive. In 8 percent of couples, only a male factor is identified.

Many things can contribute to infertility in men. These include:

  • injury to the testicles
  • age
  • excess weight or obesity
  • heavy use of alcohol, anabolic steroids, or cigarettes
  • hormonal imbalance, caused by improper function of the pituitary gland or exposure to too much estrogen or testosterone
  • medical conditions, including diabetes, cystic fibrosis, and some types of autoimmune disorders
  • cancer treatment involving certain types of chemotherapy or radiation
  • varicoceles, which are enlarged veins that cause the testicles to overheat
  • genetic disorders, such as a microdeletion in the Y-chromosome or Klinefelter syndrome

If your doctor suspects male infertility, they’ll order a semen analysis. Your doctor will use a sample of your semen to assess the sperm count as well as sperm shape and movement.


Perform initial complete pelvic and endocrinologic exam. If ovarian enlargement occurs, hold dose until ovaries return to pretreatment size, and reduce dosage or duration of next course. Polycystic ovary syndrome. Discontinue if visual disorders occur. Metabolism disorders (eg, hypertriglyceridemia). Preexisting or family history of hyperlipidemia: monitor plasma triglycerides periodically. Nursing mothers.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.