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Clomid Erectile Dysfunction

Clomid Erectile Dysfunction


Male testosterone deficiency is associated with bad sexual function and quality of life (QoL). The aim of this study was to determine whether a daily dose of 25 mg clomiphene citrate (CC) is effective in stimulating the endogenous testosterone production pathway and to address the applicability of this medication as a therapeutic option for symptomatic hypogonadism.


This was a prospective study. Men with low sexual desire and testosterone levels (T) below 400 ng/dL were selected to receive CC. Blood samples were obtained to determine baseline measurements of serum T, estradiol, LH, lipid profile and fasting plasma glucose. Each patient was treated with a daily dose of 25 mg CC for at least 3 months. Patients were asked if they experienced any side effects related to the use of CC and if they experienced any improvement in their sexual profile. Paired samples T-test was utilized to analyze responses to therapy.

General patient population

In the Center for Sexual Function, 990 men who presented with sexual dysfunction during a 2-y period were evaluated with retrospective chart review. The clinical characteristics and medical risk factors of the population were previously reported.25 All men had testosterone and luteinizing hormone levels monitored, and 58 men (5.8%) had hypergonadotropic hypogonadism (primary gonadal failure), while 302 men (30.5%) had hypogonadotropic hypogonadism (ie, low testosterone and inappropriately low or normal luteinizing hormone levels). Of these 302 men, 272 (90.7%) had ED as part of their presenting complaint, defined as the inability to achieve or maintain an erection long enough to complete sexual intercourse satisfactorily in more than 50% of attempts.

Treatment with clomiphene citrate

Of the 272 men with hypogonadotropic hypogonadism and ED, 228 (83.8%) completed a 4-month course of clomiphene citrate, 50 mg orally on Monday, Wednesday, and Friday. Most of these men were married in a stable heterosexual relationship; the single men were in a steady relationship for at least 6 months. A home log was kept in which the couple recorded the number of sexual attempts and successes at intercourse. A successful response was defined as the ability to complete intercourse in more than 75% of attempts; a partial response was defined as successful intercourse in from 50 to 75% of attempts. The men who failed did not notice any change in their sexual activity. No men reported side effects caused by clomiphene citrate.


Our data showed that a daily dose of 25mg clomiphene citrate was effective in stimulating endogenous T production in a short follow-up. On the other hand, lower levels of total cholesterol were verified after 3 months of treatment. Both objective and subjective responses to CC depended mostly on patient’s age: the younger the patient was, the greater was the increase in serum T and the chance for a positive QoL score. No serious adverse events were recorded during the study period. This medication should be considered a therapeutic option for patients with symptomatic male testosterone deficiency.

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