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Clobetasol Propionate &Salicylic Acid

Clobetasol Propionate &  Salicylic Acid

Description

Clobetasol is used to reduce the itching and inflammation in scalp and skin infections. This medicine should be applied as instructed by your doctor. Do not use beyond the prescribed date due to increase in the risk of infections.

Salicylic Acid Topical Side Effects

Salicylic acid topical can cause a rare but serious allergic reaction or severe skin irritation. These reactions may occur just a few minutes after you apply the medicine, or within a day or longer afterward.

Stop using this medicine and get emergency medical help if you have signs of an allergic reaction: hives, itching; difficult breathing, feeling light-headed; swelling of your face, lips, tongue, or throat.

Stop using salicylic acid topical and call your doctor at once if you have:

  • severe headache, ringing in your ears, problems with hearing, thinking problems;
  • severe stomach pain, vomiting, or diarrhea;
  • a light-headed feeling, like you might pass out;
  • shortness of breath; or
  • severe burning, dryness, or irritation of the skin.
  • Common side effects may include: minor skin irritation, rash, or peeling; or
  • changes in the color of treated skin (usually whitening).

Indications and Usage for Clobetasol

Clobetasol propionate ointment USP is a super-high potency corticosteroid formulation indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Treatment beyond 2 consecutive weeks is not recommended, and the total dosage should not exceed 50 g/week because of the potential for the drug to suppress the hypothalamic-pituitary-adrenal (HPA) axis. Use in pediatric patients under 12 years of age is not recommended.

As with other highly active corticosteroids, therapy should be discontinued when control has been achieved. If no improvement is seen within 2 weeks, reassessment of the diagnosis may be necessary.

Precautions

Clobetasol propionate ointment should not be used in the treatment of rosacea or perioral dermatitis, and should not be used on the face, groin, or axillae.

Systemic absorption of topical corticosteroids can produce reversible HPA axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal from treatment. Manifestations of Cushing syndrome, hyperglycemia, and glucosuria can also be produced in some patients by systemic absorption of topical corticosteroids while on therapy.

Patients applying a topical steroid to a large surface area or to areas under occlusion should be evaluated periodically for evidence of HPA axis suppression. This may be done by using the ACTH stimulation, A.M. plasma cortisol, and urinary free cortisol tests. Patients receiving super-potent corticosteroids should not be treated for more than 2 weeks at a time, and only small areas should be treated at any one time due to the increased risk of HPA suppression.

Dosage

Missed Dose

Apply the missed dose as soon as you remember. Do not apply if it is almost time for your next dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.

Warnings

Warnings for special population

  • Pregnancy - This medicine is not recommended for pregnant women unless necessary. The benefits and risks should be discussed with the doctor before receiving this medicine.
  • Breast-feeding - This medicine is not recommended in breastfeeding women. Short-term application of this medicine may not cause any harm to the baby. The benefits and risks should be discussed with the doctor before receiving this medicine.

General warnings

  • Chronic application - Chronic application of this medicine may affect the growth and development in children.
  • Cushing's syndrome - This medicine may cause hypothalamic-pituitary-adrenal (HPA) axis suppression and causes Cushing's syndrome in patients receiving high doses for a prolonged period. Any symptoms of swelling of the face, increase in the blood glucose levels should be informed to the doctor.
  • Use in childrem - This medicine in not recommended in children less than 12 years.
  • Infections - This medicine may increase the risk of infections. Appropriate antibiotic treatment should be started to prevent the spread of infection.
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