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Clindamycin Phosphate Gel

Clindamycin Phosphate Gel

Mechanism of Action

Although clindamycin phosphate is inactive in vitro, rapid in vitro hydrolysis converts this compound to clindamycin which has antibacterial activity. Clindamycin inhibits bacteria protein synthesis at the ribosomal level by binding to the 50S ribosomal subunit and affecting the process of peptide chain initiation. (from FDA label)

How Clindamycin Phosphate Gel Works

Clindamycin Phosphate gel is an antibiotic that targets acne causing bacteria and prevents it from replicating. In this way, this antibiotic acne treatment does not kill bacteria but prevents it from reproducing. Through regular application of Clindamycin Phosphate gel, the number of acne bacteria inside your skin will decrease, which will reduce inflammation and pimple size.

Typical results from Clindamycin Phosphate gel will take about 1-2 months to show, as the gel helps speed up the acne healing process, but doesn’t cure acne overnight. Keep in mind that this topical ointment is certainly not a spot treatment, and you’ll need to explore other options if you need to get rid of acne fast; such as before a wedding or another major life event where you want to look your best.

How do I use Zindaclin gel?

Zindaclin gel should be applied thinly to the whole area of skin affected by acne (not just the individual spots) once a day.

Wash your skin with a mild cleanser and pat it dry before applying Zindaclin. Gently apply a thin layer of gel using your fingertips or a cotton pad. Wash your hands after application.

Take care to avoid getting Zindaclin on your eyelids or lips, or in your eyes, nose or mouth. If you accidentally get the gel on these areas, wash it off with water.

You can use moisturisers or cosmetics after applying Zindaclin, but wait until it has dried.

Side effects and warnings

"Clindamycin can cause some stomach distress, as most antibiotics do," said Sternfeld. Other less serious side effects include:

  • joint pain
  • pain when swallowing
  • heartburn
  • white patches in the mouth
  • head or backaches

Other, more serious side effects should be treated by a doctor immediately, including:

  • blisters
  • rash
  • hives
  • difficulty breathing or swallowing
  • yellowing of the skin or eyes
  • decreased urination
  • fever, chills, and other flu-like symptoms
  • sores on mouth or throat
  • easy bruising or red or purple pinpoint spots under the skin
  • unusual bleeding (of the nose, mouth, vagina, or rectum)
  • facial swelling

There are no known reactions between alcohol or certain foods and clindamycin, so the normal diet can be continued unless a doctor says otherwise.

Women who are pregnant or planning to become pregnant should consult a doctor before taking clindamycin.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.