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Cisplatin Side Effects Long Term

Cisplatin Side Effects Long Term

Description

Gastrointestinal - Marked nausea and vomiting occur in almost all patients treated with cisplatin (cisplatin injection) , and are occasionally so severe that the drug must be discontinued. Nausea and vomiting usually begin within 1 to 4 hours after treatment and last up to 24 hours.

What Cisplatin Is Used For

Treatment of advanced bladder cancer, metastatic ovarian cancer, and metastatic testicular cancer. Testicular, ovarian, bladder, head and neck, esophageal, small and non-small cell lung, breast, cervical, stomach and prostate cancers. Also to treat Hodgkin's and non-Hodgkin's lymphomas, neuroblastoma, sarcomas, multiple myeloma, melanoma, and mesothelioma.

How it Work?

The ability of chemotherapy to kill cancer cells depends on its ability to halt cell division. Usually, the drugs work by damaging the RNA or DNA that tells the cell how to copy itself in division. If the cells are unable to divide, they die. The faster the cells are dividing, the more likely it is that chemotherapy will kill the cells, causing the tumor to shrink. They also induce cell suicide (self-death or apoptosis).

Long Term Side Effects of Chemotherapy for Cancer

The long-term side effects of chemotherapy are important to understand, even though the benefits of treatment usually far outweigh these potential risks. Many people are familiar with symptoms such as hair loss and nausea, but there are less well known symptoms that may persist or arise months to years after treatment has been completed.Before addressing possible long term side effects, keep in mind that everyone is different. Some people may have several of these side effects, while many will have none. Side effects also vary considerably depending on the particular chemotherapy medications that are used.

Side Effect

  • Peripheral neuropathy: Although less common, a serious side effect of decreased sensation and paresthesia (numbness and tingling of the extremities) may be noted. Sensory loss, numbness and tingling, and difficulty in walking may last for at least as long as therapy is continued. These side effects may become progressively more severe with continued treatment, and your doctor may decide to decrease your dose. Neurologic effects may be irreversible.
  • Loss of appetite
  • Taste changes, metallic taste
  • Increases in blood tests measuring liver function. These return to normal once treatment is discontinued. (see liver problems).
  • Hair loss may cause hair loss; however, this side effect is uncommon.

Precaution

  • Your fertility, meaning your ability to conceive or father a child, may be affected by cisplatin. Please discuss this issue with your health care provider.
  • Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category D (Cisplatin may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus).
  • For both men and women: Use contraceptives, and do not conceive a child (get pregnant) while taking cisplatin. Barrier methods of contraception, such as condoms, are recommended. Discuss with your doctor when you may safely become pregnant or conceive a child after therapy.

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