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Cisplatin Nephrotoxicity

Cisplatin Nephrotoxicity

Is cisplatin nephrotoxic?

Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in renal function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose limiting.

CISPLATIN NEPHROTOXICITY

Nephrotoxicity was reported in the initial clinical trials of cisplatin chemotherapy.17 Now, it is recognized that the prevalence of cisplatin nephrotoxicity is high, occurring in about one-third of patient undergoing cisplatin treatment.4,18 Clinically, cisplatin nephrotoxicity is often seen after 10 days of cisplatin administration and is manifested as lower glomerular filtration rate, higher serum creatinine, and reduced serum magnesium and potassium levels.4., 19., 20. On the other hand, the long-term effects of cisplatin on renal function are not completely understood, but it is believed that cisplatin treatment may lead to subclinical but permanent reduction in glomerular filtration rate.

Uses

Treatment of advanced bladder cancer, metastatic ovarian cancer, and metastatic testicular cancer. Testicular, ovarian, bladder, head and neck, esophageal, small and non-small cell lung, breast, cervical, stomach and prostate cancers. Also to treat Hodgkin's and non-Hodgkin's lymphomas, neuroblastoma, sarcomas, multiple myeloma, melanoma, and mesothelioma.

How Cisplatin Is Given

  • Cisplatin is administered through a vein (intravenously or IV) as an infusion.
  • There is no pill form of cisplatin.
  • Cisplatin is an irritant. An irritant is a chemical that can cause inflammation of the vein through which it is given.
  • If cisplatin escapes from the vein it can cause tissue damage. The nurse or doctor who gives cisplatin must be carefully trained. If you experience pain or notice redness or swelling at the IV site while you are receiving cisplatin, alert your health care professional immediately.
  • Before and/or after the cisplatin infusion, extra IV fluids are given and care is taken to ensure adequate hydration before both during and after cisplatin, to protect your kidney function.

Side Effect

  • Nausea and vomiting. Nausea may last up to 1 week after therapy. ...
  • Low blood counts. ...
  • Kidney toxicity. ...
  • Ototoxicity hearing loss, ringing in the ears.
  • Blood test abnormalities (low magnesium, low calcium, low potassium)

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