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Cisplatin Mannitol

Cisplatin Mannitol

Why is mannitol used with cisplatin?

The adverse effect profile of cisplatin is well documented, but the prevention strategies to alleviate renal impairment due to treatment are less understood. Mannitol plus hydration has been used for several years to alleviate toxicity associated with cisplatin therapy.

Uses

Treatment of advanced bladder cancer, metastatic ovarian cancer, and metastatic testicular cancer. Testicular, ovarian, bladder, head and neck, esophageal, small and non-small cell lung, breast, cervical, stomach and prostate cancers. Also to treat Hodgkin's and non-Hodgkin's lymphomas, neuroblastoma, sarcomas, multiple myeloma, melanoma, and mesothelioma.

Side Effect

  • Most people do not experience all of the cisplatin side effects listed.
  • Cisplatin side effects are often predictable in terms of their onset, duration, and severity.
  • Cisplatin side effects will improve after therapy is complete.
  • Cisplatin side effects may be quite manageable. There are many options to help minimize or prevent the side effects of cisplatin.
  • There is no relationship between the presence or severity of Cisplatin side effects and effectiveness of cisplatin.

Precaution

  • Before starting cisplatin treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, products containing aspirin unless your doctor specifically permits this.
  • Cisplatin may be inadvisable if you have a history of severe allergic reaction to cisplatin, carboplatin, other platinum-containing formulations or mannitol.
  • Do not receive any kind of immunization or vaccination without your doctor's approval while taking cisplatin.
  • Your fertility, meaning your ability to conceive or father a child, may be affected by cisplatin. Please discuss this issue with your health care provider.

Purpose

The aim of this study was to evaluate the incidence of cisplatin induced nephrotoxicity in patients treated with and without mannitol. Specfically, the study tested if the addition of mannitol to cisplatin reduced signficantly the increase in serum creatinine from baseline and the incidence of acute nephrotoxicity.

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