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Cisplatin Dosage

Cisplatin Dosage

Description

Exactly assessing tumor response to different dose of chemotherapy would help to tailor therapy for individual patients. This study was to determine the feasibility of dynamic contrast-enhanced ultrasound (CEUS) in the evaluation of tumor vascular response to different dose cisplatin.

Dosages

Usual Adult Dose for Testicular Cancer:Metastatic testicular tumors: 20 mg/m2 IV over 6 to 8 hours daily for 5 days per cycle in combination with other approved chemotherapeutic agents

Usual Adult Dose for Ovarian Cancer

Metastatic Ovarian Tumors:

  • As a single agent: 100 mg/m2 IV over 6 to 8 hours per cycle once every 4 weeks
  • In combination with cyclophosphamide (give sequentially): Cisplatin 75 to 100 mg/m2 IV over 6 to 8 hours per cycle once every 4 weeks (Day 1); the dose of cyclophosphamide when used in combination with cisplatin is 600 mg/m2 IV once every 4 weeks

Usual Adult Dose for Bladder Cancer:50 to 70 mg/m2 IV over 6 to 8 hours per cycle once every 3 to 4 weeks depending on the extent of prior exposure to radiation therapy and/or prior chemotherapy; for heavily pretreated patients an initial dose of 50 mg/m2 per cycle repeated every 4 weeks is recommended

Renal Dose Adjustments:Contraindicated in patients with preexisting renal impairment.

Precaution

This drug should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. Appropriate management of therapy and complications is possible only when diagnostic and treatment facilities are readily available.Cumulative renal toxicity associated with this drug is severe.Other major dose-related toxicities are myelosuppression, nausea, and vomiting.This drug can cause ototoxicity (may be more pronounced in children) which is manifested by tinnitus, and/or loss of high frequency hearing and occasionally deafness.

Side Effect

  • Black, tarry stools
  • blood in urine or stools
  • cough or hoarseness accompanied by fever or chills
  • dizziness or faintness (during or shortly after a dose)
  • fast heartbeat (during or shortly after a dose)
  • fever or chills
  • lower back or side pain accompanied by fever or chills
  • painful or difficult urination accompanied by fever or chills
  • pain or redness at place of injection
  • pinpoint red spots on skin

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