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Cisplatin And Etoposide

Cisplatin And Etoposide

Description

Etoposide and irinotecan are key drugs in the treatment of small-cell lung cancer. We did this study to investigate whether combined chemotherapy with cisplatin, etoposide, and irinotecan was superior to topotecan monotherapy as second-line chemotherapy in patients with sensitive relapsed small-cell lung cancer.

Interpretation

Combination chemotherapy with cisplatin plus etoposide plus irinotecan could be considered the standard second-line chemotherapy for selected patients with sensitive relapsed small-cell lung cancer.

PURPOSE

The cisplatin and etoposide had been reported to be an effective anti-tumor drug for small cell lung cancer, ovarian cancer, breast cancer and so on. The aim of this study was to evaluate the stability of cisplatin and etoposide in aqueous solution.

How does Cisplatin + Etoposide work?

Cisplatin + Etoposide are designed to kill cancer cells by damaging DNA and preventing the lung cancer cells from dividing into new cells.

Side Effect

  • Often causes temporary hair loss, which is usually reversible after stopping etoposide therapy
  • Gastrointestinal side effects such as diarrhea, mouth sores, nausea and upset stomach can be common
  • Although rare, it has been linked to the development of acute leukemia (2-12%) and typically occurs 2-3 years after therapy
  • May cause low blood counts (white blood cells, red blood cells, and platelets)

Common Side Effect

  • Anemia [low red blood cell count] (85%)
  • Vomiting (60 - 70%)
  • Weight loss (58 - 68%)
  • Increased bleeding risk [low platelet count] (65%)
  • Esophagus inflammation (37 - 56%)
  • Fever (38 - 45%)
  • Infection (20 - 27%)

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